Effects of nasal ventilation on brain and lung function in intubated patients
Official title: Effects of Nasal Ventilation on Cerebral and Pulmonary Function in Orally Intubated Patients
Run by Assistance Publique - Hôpitaux de Paris · NCT06438302 · Data updated 2026-11-12
This study tests how using nasal ventilation affects brain and lung function in patients who are intubated due to severe breathing problems.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 22 (estimated) |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Paris) |
| Status | Recruiting |
| Started | January 31, 2025 |
| Main results expected | February 1, 2028 |
| Study ends | February 1, 2028 |
| Registry record updated | December 3, 2025 |
| Trial ID | NCT06438302 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older with hypoxemic acute respiratory failure who have been intubated for less than four days.
✕Probably not a fit
Patients with central nervous system diseases, psychiatric illnesses, or hemodynamic instability may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates how nasal ventilation impacts cerebral and pulmonary function in patients who are orally intubated due to hypoxemic acute respiratory failure. It aims to evaluate the modulation of brain activity and tissue oxygenation through the application of humidified nasal airflow at varying rates. The study will measure electroencephalogram (EEG) activity and assess changes in cerebral perfusion, oxygenation, and regional pulmonary ventilation under different conditions. The findings could provide insights into the importance of nasal ventilation in improving outcomes for intubated patients.
Why it matters
Potential benefit: If successful, this study could enhance the management of intubated patients by improving brain activity and pulmonary function through nasal ventilation.
How similar studies have gone: While the specific approach of this study may be novel, similar studies have indicated that nasal ventilation can positively influence respiratory and cognitive outcomes.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age ≥ 18 years old 2. Hypoxemic acute respiratory failure 3. Intubation and mechanical ventilation since less than 4 days 4. PaO2/FiO2 ratio less than 200 5. RASS\<-4 6. Consent obtained from next of kin 7. Patient with health insurance Exclusion Criteria: 1. Central nervous system diseases (stroke, MS, epilepsy) 2. Psychiatric illnesses (psychosis, depression) (indicated on patient's medical record) 3. Hemodynamic instability (noradrenalin\>2mg/h) 4. Patient on AME 5. Patients under legal protection (guardianship/curators) 6. Pregnant or breast-feeding women
Where it's running
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Service de Médecine Intensive Réanimation - Hôpital Pitié -Salpêtrière
Paris, France Recruiting
Study contacts
- Study coordinator: Martin Dres
- Email: martin.dres@aphp.fr
- Phone: 0142167809
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Apneic oxygenation with high-flow nasal oxygen during intubation in hypoxemic ICU patients
This study tests whether using high-flow nasal oxygen during the pause between laryngoscopy and successful intubation helps prevent severe low oxygen levels in ICU patients with hypoxemic respiratory failure.
-
Comparing SpO2 targets and oximeters during high-flow nasal oxygen
This study tests whether two different pulse oximeters (Nonin and Philips) and two SpO2 targets (90% vs 94%) change the amount of oxygen (FiO2) set for adults in the ICU receiving high-flow nasal oxygen.
-
Improving oxygen delivery in critically ill patients on ventilators
This study is testing if a new automatic system for controlling oxygen can help critically ill patients on ventilators keep their oxygen levels stable better than the usual manual method.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.