Effects of nasal ventilation on brain and lung function in intubated patients
Effects of Nasal Ventilation on Cerebral and Pulmonary Function in Orally Intubated Patients
This study tests how using nasal ventilation affects brain and lung function in patients who are intubated due to severe breathing problems.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 22 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Paris) |
| Trial ID | NCT06438302 on ClinicalTrials.gov |
What this trial studies
This observational study investigates how nasal ventilation impacts cerebral and pulmonary function in patients who are orally intubated due to hypoxemic acute respiratory failure. It aims to evaluate the modulation of brain activity and tissue oxygenation through the application of humidified nasal airflow at varying rates. The study will measure electroencephalogram (EEG) activity and assess changes in cerebral perfusion, oxygenation, and regional pulmonary ventilation under different conditions. The findings could provide insights into the importance of nasal ventilation in improving outcomes for intubated patients.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with hypoxemic acute respiratory failure who have been intubated for less than four days.
Not a fit: Patients with central nervous system diseases, psychiatric illnesses, or hemodynamic instability may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the management of intubated patients by improving brain activity and pulmonary function through nasal ventilation.
How similar studies have performed: While the specific approach of this study may be novel, similar studies have indicated that nasal ventilation can positively influence respiratory and cognitive outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age ≥ 18 years old 2. Hypoxemic acute respiratory failure 3. Intubation and mechanical ventilation since less than 4 days 4. PaO2/FiO2 ratio less than 200 5. RASS\<-4 6. Consent obtained from next of kin 7. Patient with health insurance Exclusion Criteria: 1. Central nervous system diseases (stroke, MS, epilepsy) 2. Psychiatric illnesses (psychosis, depression) (indicated on patient's medical record) 3. Hemodynamic instability (noradrenalin\>2mg/h) 4. Patient on AME 5. Patients under legal protection (guardianship/curators) 6. Pregnant or breast-feeding women
Where this trial is running
Paris
- Service de Médecine Intensive Réanimation - Hôpital Pitié -Salpêtrière — Paris, France (Recruiting)
Study contacts
- Study coordinator: Martin Dres
- Email: martin.dres@aphp.fr
- Phone: 0142167809
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.