Effects of nasal high flow on exercise tolerance in COPD patients
Official title: Physiologic Effects of Nasal High Flow on Exercise Tolerance in Chronic Obstructive Pulmonary Disease (COPD)
Run by University of Miami · NCT06578156 · Data updated 2026-11-12
This study is testing if using a high flow nasal oxygen therapy can help people with COPD walk longer and feel less short of breath during exercise compared to regular low flow oxygen.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 100 Years |
| Sex | All |
| Enrollment | 45 (estimated) |
| Sponsor | University of Miami Academic / other |
| Locations | 1 site (Miami, Florida) |
| Status | Recruiting |
| Started | December 12, 2024 |
| Main results expected | December 31, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | June 22, 2026 |
| Trial ID | NCT06578156 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older diagnosed with COPD who can walk independently and use low-flow oxygen.
✕Probably not a fit
Patients who are pregnant, on bedrest, or require high-flow oxygen or non-invasive ventilation during the day may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the impact of nasal high flow (NHF) therapy at 70 liters per minute on exercise tolerance in patients with Chronic Obstructive Pulmonary Disease (COPD) using a 6-Minute Walk Test (6-MWT). It aims to determine the relationship between self-reported dyspnea and the use of NHF compared to low flow nasal cannula during exercise. The study will involve COPD patients who can ambulate independently and are currently using low-flow oxygen or none at all. Participants will be monitored for their exercise performance and breathing difficulties during the test.
Why it matters
Potential benefit: If successful, this study could improve exercise tolerance and quality of life for COPD patients by optimizing oxygen delivery during physical activity.
How similar studies have gone: Other studies have shown promising results with nasal high flow therapy in respiratory conditions, suggesting potential benefits in similar approaches.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Able to consent * Age 18 years or older * Diagnosis of COPD * Ability to ambulate without assistance * Use of low-flow nasal cannula ≤ 4 L/min or no supplemental oxygen (O2) at all Exclusion Criteria: * Pregnancy * Being on bedrest * Inability to consent or cooperate with the study * Using of \> 4 L/min of supplemental O2 or requiring non-invasive ventilation during the daytime * Hemodynamic instability (resting heart rate \> 130/minute, systolic blood pressure of ≤ 90 mmHg or ≥ 180 mmHg) * Metal implants in the thoracic regions (pacemakers, Automatic Implantable Cardioverter Defibrillator (AICD), plates, screws, rods, and disc replacements)
Where it's running
-
University of Miami
Miami, Florida, United States Recruiting
Study contacts
- Principal investigator: Saramaria Afanador Castiblanco, M.D. — University of Miami
- Study coordinator: Saramaria Afanador Castiblanco, M.D.
- Email: saramaria.afanador@miami.edu
- Phone: 305-243-2568
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
AERO-007: a inhaled LABA+LAMA combination for COPD through a nebulizer
This study tests whether a nebulized LABA+LAMA combination can improve lung function in adults with COPD.
-
Cognitive load and inhaler technique in COPD
This study tests whether adding a short memory task while using an inhaler makes COPD patients more likely to misuse their inhaler.
-
Balance training after pulmonary rehab for COPD to help steadiness and reduce falls
A COPD-focused balance training program called Sport4Steadiness is being tested to see if people with COPD will accept it and if the study processes work well.
-
Continuous vs High-Intensity Interval Exercise in COPD
This study tests whether continuous versus high-intensity interval exercise affects cerebral oxygenation in people with COPD.
-
Biomarker clues for COPD, IPF, and lung cancer
This study tests whether inflammation, immune, genetic, and epigenetic markers at enrollment can explain how COPD, IPF, or lung cancer present and behave, in order to see if these markers can predict outcomes over a year.
-
HRS-9821 Inhalation Suspension for COPD: Safety and Dose Finding in Adults
This study tests whether HRS-9821 inhalation can be safely taken and help people with moderate to severe COPD, and aims to find a reasonable dose.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.