Effects of muscle training and early mobilization on patients on mechanical ventilation
Official title: Short Effects of Speci|c Inspiratory Muscle Training and Early Mobilization in Prolonged Mechanically Ventilated Patients
Run by Prince of Songkla University · NCT06368089 · Data updated 2026-11-12
This study tests if muscle training and early movement can help patients on mechanical ventilation breathe better and get off the ventilator sooner.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 40 Years to 80 Years |
| Sex | All |
| Enrollment | 46 (estimated) |
| Sponsor | Prince of Songkla University Academic / other |
| Locations | 1 site (Songkhla) |
| Status | Recruiting |
| Started | May 6, 2024 |
| Main results expected | February 2026 |
| Study ends | March 2026 |
| Registry record updated | November 6, 2024 |
| Trial ID | NCT06368089 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients aged 40 to 80 with respiratory diseases who have been on mechanical ventilation for more than 48 hours and are ready for weaning.
✕Probably not a fit
Patients who are clinically unstable or can be extubated within the first 24 hours may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the impact of inspiratory muscle training and early mobilization on patients who have been mechanically ventilated for over 48 hours. It aims to compare the effects of these interventions on dynamic lung compliance and maximum inspiratory pressure before and after a 7-day training period. Additionally, the study will evaluate the success rate and duration of weaning from mechanical ventilation between the two groups. The goal is to enhance respiratory muscle strength and mobility to facilitate successful weaning.
Why it matters
Potential benefit: If successful, this study could improve the weaning process from mechanical ventilation, leading to better recovery outcomes for patients.
How similar studies have gone: Other studies have shown promising results with similar approaches, indicating potential for success in this area.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with respiratory diseases who have been on mechanical ventilation for more than 48 hours and are ready to be weaned off or undergoing weaning trials with continuous positive airway pressure (CPAP) or synchronized intermittent mandatory ventilation (SIMV). * The PaO2/FiO2 ratio is ≥ 150-200, with FiO2 ≤ 0.4-0.5 and PEEP ≤ 5-8 cmH2O, and a pH \> 7.3 in blood plasma. * The age range is between 40 and 80 years old. * Patients exhibit good self-awareness and cooperation in training (Riker score of 4). * They can understand and communicate in Thai Exclusion Criteria: * Clinical instability (HR \> 120 beats/minute, RR \> 30 breaths/minute, SatO2 \< 90%, SBP \> 140 mmHg or \< 90 mmHg) * Patients who can be extubated and use non-invasive ventilation only or successfully extubated within the first 24 hours. * Patients with altered mental status (Glasgow Coma Score \< 10) and inability to cooperate with training (Riker score \< 4 or \> 4) * Patients with limitations or contraindications such as inability to adjust the bed to a 45-degree angle or sit on the side of the bed, such as those with spinal cord injuries or recent head surgeries. * History of hemoptysis, pneumothorax * History of neuromuscular diseases causing muscle weakness and decreased sensation. * Patients with excessive cardiac stimulation (\> 5 micrograms per kilogram per minute) * Heart rate \> 140 beats per minute * Hemoglobin levels \< 8-10 grams per deciliter * Patients with difficult airway issues.
Where it's running
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Medical Respiratory Care Unit (MRCU), Prince of Songklanakarind Hospital
Songkhla, Thailand Recruiting
Study contacts
- Principal investigator: Saikaew Chuachan — Department of Physical Therapy, Faculty of Medicine, PSU
- Study coordinator: Saikaew Chuachan, Msc.PT
- Email: saikaew.ch@psu.ac.th
- Phone: 0849988665
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Powered lower-limb exoskeleton training for adults with prolonged mechanical ventilation
We are testing whether using a powered leg exoskeleton during training can improve leg strength, breathing measures, and recovery time for people who have been on a ventilator for a long period.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.