Effects of morning vs evening exercise on blood pressure in older women
Effects of AM vs. PM Exercise Training on Blood Pressure and Vascular Health in Postmenopausal Females With Hypertension
This study tests whether exercising in the morning or evening can help lower blood pressure in older women with high blood pressure.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 79 (estimated) |
| Ages | 55 Years to 80 Years |
| Sex | Female |
| Sponsor | Michigan State University Academic / other |
| Locations | 1 site (East Lansing, Michigan) |
| Trial ID | NCT06042439 on ClinicalTrials.gov |
What this trial studies
This study investigates how the timing of exercise—either in the morning or early evening—affects blood pressure and vascular health in postmenopausal women with hypertension. Participants will undergo a 6-week exercise training program, with assessments of blood pressure and vascular function before and after the training. The research aims to explore the potential benefits of aligning exercise with the body's natural rhythms to improve cardiovascular health. This approach builds on previous findings that evening medication may be more effective for managing hypertension.
Who should consider this trial
Good fit: Ideal candidates are postmenopausal females aged 55-80 with hypertension who are not habitually physically active.
Not a fit: Patients with significant cardiometabolic diseases or those who are already physically active may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a new, effective lifestyle intervention for managing hypertension in older women.
How similar studies have performed: While there is evidence supporting the effectiveness of chronotherapy with medications, this specific approach combining exercise timing with hypertension management is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Systolic BP equal to or greater than 130 mmHg without BP medication or greater than 120 mmHg with medication and diastolic blood pressure equal to and greater than 80 mmHg * 55-80 years old * Post-menopausal female * Able to walk without assistance Exclusion Criteria: * Habitually physically active defined as 150 minutes of moderate-intensity or 75 minutes of vigorous-intensity aerobic physical activity per week * Overt pulmonary disease/condition as follows: chronic bronchitis, chronic obstructive pulmonary disease, emphysema, or pulmonary hypertension * Cardiometabolic disease/condition as follows: diabetes, heart failure, peripheral arterial disease, stroke, coronary artery disease, renal disease, secondary hypertension, chronic venous insufficiency or deep vein thrombosis within last 6 months * Cancer within last 5 years * Body mass index \>39 kg/m2 * Current smoking or vape * Evening shift work * uncontrolled thyroid disorder * 2 or more falls in the last year * Anemia within 3 months of enrollment * Parkinson's disease * Dementia * Unstable angina * Acute pulmonary embolus or infarction * Acute myocarditis or pericarditis * Acute aortic dissection
Where this trial is running
East Lansing, Michigan
- Michigan State University — East Lansing, Michigan, United States (Recruiting)
Study contacts
- Study coordinator: Jill Slade, PhD
- Email: jslade@msu.edu
- Phone: 5178843351
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.