Effects of melatonin on heart responses during exercise and cold exposure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This experiment aims to investigate how acute melatonin supplementation influences cardiovascular responses during sympathetic activation, specifically through a cold pressor test and dynamic exercise. Participants will undergo three visits, including a screening and two experimental sessions where they will receive either melatonin or a placebo in a randomized, single-blind design. Measurements will be taken at rest and during exercise to assess changes in cardiovascular function. The study is conducted at the University of Oklahoma's Human Circulation Research Laboratory.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy men and women
* Women must be premenopausal with a regular menstrual cycle (26-30 days)

Exclusion Criteria:

* History of autonomic dysfunction
* Cardiovascular diseases
* Diabetes
* Tobacco/nicotine use
* Systolic Pressure \>= 130 mmHg
* Diastolic Pressure \>= 85 mmHg
* Regular melatonin use \>= 1 use/week
* Allergy to melatonin
* Cardiometabolic medication use (e.g. anti-hypertensives, insulin-sensitizing, statins)
* Sex hormone replacement medical use (e.g. testosterone, estrogen, progesterone)
* Pregnancy

Where it's running

• Department of Health and Exercise Science
  Norman, Oklahoma, United States Recruiting

Study contacts

• Principal investigator: Jeremy M Kellawan — University of Oklahoma
• Study coordinator: Jeremy M Kellawan, PhD
• Email: kellawan@ou.edu
• Phone: 405 325 9028

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.