Effects of meals with potatoes and protein on blood sugar and hunger

Postprandial Glycemia and Satiety of Meals With Potatoes, With and Without Protein

This study is testing how meals with potatoes and different types of protein affect blood sugar levels and how hungry people feel afterward.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 30 (estimated)
• Ages: 18 Years to 45 Years
• Sex: All
• Sponsor: University of Toronto (other)
• Locations: 1 site (Toronto, Ontario)
• Trial ID: NCT05610124 on ClinicalTrials.gov

What this trial studies

This study investigates how different meal compositions, specifically those containing potatoes and varying protein sources, affect post-meal blood sugar levels and feelings of fullness. A total of 30 participants will consume meals with fixed protein amounts from either beef or vegetarian substitutes, alongside ad libitum access to mashed potatoes, fries, or pasta. Blood samples will be taken to measure glucose, insulin, and ghrelin levels, while participants will also complete questionnaires regarding their appetite and food intake. The study aims to understand the relationship between meal composition and glycemic control, as well as appetite regulation.

Who should consider this trial

Good fit: Ideal candidates are healthy adults aged 18 to 45 with a BMI between 18.5 and 24.9 who can maintain their usual diet and activity levels during the study.

Not a fit: Patients with smoking habits, thyroid problems, or a history of cardiovascular disease may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide insights into meal planning for better glycemic control and appetite management in individuals with diabetes and obesity.

How similar studies have performed: Other studies have shown promising results in understanding the effects of meal composition on glycemic control, making this approach both relevant and potentially impactful.

Eligibility criteria

Inclusion Criteria:

* \> 18 and \< 45 years of age
* BMI \> 18.5 and \< 24.9 kg/m2
* Willing to maintain habitual diet, physical activity pattern, and body weight throughout the study.
* Willing to maintain current dietary supplement use throughout the study. On test days, subject agrees not to take any dietary supplements until dismissal from the Nutrition Intervention Center. Failure to comply will result in a rescheduled test visit.
* Willing to abstain from alcohol consumption for 24h prior to all test visits.
* Willing to refrain from marijuana/ edibles use for the duration of the study (approximately 6 weeks).
* Willing to avoid vigorous physical activity for 24h prior to all test visits.
* Understanding the study procedure and willing to provide informed consent to participate in the study and authorization to release relevant protected health information to the study investigator.

Exclusion Criteria:

* Smoking
* Thyroid problems
* Previous history of cardiovascular disease, diabetes, liver or kidney disease, inflammatory bowel disease, celiac disease, short bowel syndrome, a malabsorptive syndrome, pancreatitis, gallbladder or biliary disease.
* Presence of a gastrointestinal disorder or surgeries within the past year.
* Known to be pregnant or lactating.
* Unwillingness or inability to comply with the experimental procedures and to follow our safety guidelines.
* Known intolerances, sensitivity or allergy to any ingredients in the study products.
* Extreme dietary habits (i.e Atkins diet, very high protein diets, etc.) or restrained eaters, identified by a score of ≥ 11 on the Eating Habits Questionnaire
* Uncontrolled hypertension (systolic blood pressure \> 140 mm Hg or diastolic blood pressure \> 90 mm Hg) as defined by the average blood pressure measured at screening.
* Weight gain or loss of at least 10lbs in previous three months.
* Excessive alcohol intake (more than 2 drinks per day or more than 9 drinks per week).
* Consuming prescription or non-prescription drug, herbal or nutritional supplements known to affect blood glucose or that could affect the outcome of the study as per investigator's judgment.

Where this trial is running

Toronto, Ontario

• University of Toronto - Department of Nutritional Sciences — Toronto, Ontario, Canada (RECRUITING)

Study contacts

• Principal investigator: G. Harvey Anderson, PhD — University of Toronto
• Study coordinator: Amira Amr, PhD

Conditions: Glycemic Control, Satiety Response, Appetite Regulation, Diabetes, Obesity, Satiety, Appetite, Potato