Effects of magnesium sulfate on blood clotting after laparoscopic gynecological surgeries
Effect of Magnesium Sulfate on Postoperative Hypercoagulability Using Thromboelastometry in Laparoscopic Gynecological Surgeries
This study is testing if giving magnesium sulfate after laparoscopic gynecological surgeries can help reduce the risk of blood clots in patients.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | Aretaieion University Hospital Academic / other |
| Locations | 1 site (Athens, Attica) |
| Trial ID | NCT06717490 on ClinicalTrials.gov |
What this trial studies
This prospective randomized, double-blind study investigates how magnesium sulfate affects postoperative hypercoagulability in patients undergoing laparoscopic gynecological surgeries under general anesthesia. Participants are randomly assigned to receive either magnesium sulfate or a placebo (normal saline), with both patients and investigators unaware of the treatment allocation. The study utilizes thromboelastometry to measure various blood coagulation parameters, including clotting time and coagulation markers, to determine the therapeutic potential of magnesium sulfate in reducing hypercoagulability after surgery.
Who should consider this trial
Good fit: Ideal candidates include ASA I and II patients over 18 years old undergoing laparoscopic gynecological surgeries who are receiving prophylactic anticoagulant therapy.
Not a fit: Patients with ASA classification III or higher, those under 18 years old, or those with significant comorbidities such as severe anemia or known hematologic disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management of postoperative blood clotting, reducing the risk of complications for patients undergoing laparoscopic gynecological surgeries.
How similar studies have performed: While the specific application of magnesium sulfate in this context may be novel, similar studies investigating anticoagulant therapies have shown promising results in managing postoperative hypercoagulability.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * ASA I and II patients * Laparoscopic gynecological surgeries * age \>18 years * Patients receiving prophylactic anticoagulant therapy 12 hours before surgery based on the Caprini score * Patients receiving prophylactic anticoagulant therapy 12 hours postoperatively based on the Caprini score. Exclusion Criteria: * ASA ≥ III * age \<18 years * BMI \>40 kg/m² * Pregnancy * Known hematologic disorders * Liver/kidney/cardiovascular disease * Severe anemia (6,5- 7,9 g/dl) * Inability or refusal to provide informed consent
Where this trial is running
Athens, Attica
- Aretaieion University Hospital — Athens, Attica, Greece (Recruiting)
Study contacts
- Study coordinator: Marianna Mavromati, MD
- Email: marimavr14@gmail.com
- Phone: 0030 6975630647
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.