Effects of magnesium sulfate on blood clotting after laparoscopic gynecological surgeries

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective randomized, double-blind study investigates how magnesium sulfate affects postoperative hypercoagulability in patients undergoing laparoscopic gynecological surgeries under general anesthesia. Participants are randomly assigned to receive either magnesium sulfate or a placebo (normal saline), with both patients and investigators unaware of the treatment allocation. The study utilizes thromboelastometry to measure various blood coagulation parameters, including clotting time and coagulation markers, to determine the therapeutic potential of magnesium sulfate in reducing hypercoagulability after surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ASA I and II patients
* Laparoscopic gynecological surgeries
* age \>18 years
* Patients receiving prophylactic anticoagulant therapy 12 hours before surgery based on the Caprini score
* Patients receiving prophylactic anticoagulant therapy 12 hours postoperatively based on the Caprini score.

Exclusion Criteria:

* ASA ≥ III
* age \<18 years
* BMI \>40 kg/m²
* Pregnancy
* Known hematologic disorders
* Liver/kidney/cardiovascular disease
* Severe anemia (6,5- 7,9 g/dl)
* Inability or refusal to provide informed consent

Where it's running

• Aretaieion University Hospital
  Athens, Attica, Greece Recruiting

Study contacts

• Study coordinator: Marianna Mavromati, MD
• Email: marimavr14@gmail.com
• Phone: 0030 6975630647

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Dexmedetomidine vs magnesium as intraperitoneal add-ons to bupivacaine for laparoscopic gallbladder removal

  This study tests whether adding dexmedetomidine or magnesium sulfate to bupivacaine injected inside the abdomen provides better pain relief after laparoscopic cholecystectomy for adults without serious health issues.

  Recruiting Alexandria University · Alexandria · NCT07693621

• Anesthesia methods, neuroprotection, and surgical field in FESS with controlled hypotension

  This trial tests whether four different anesthesia maintenance techniques — propofol-remifentanil, propofol-remifentanil with ketamine and magnesium, sevoflurane-remifentanil, and sevoflurane-remifentanil with ketamine and magnesium — better protect the brain and improve the surgical field in adults having FESS under c

  Recruiting University General Hospital of Patras · Pátrai, Achaia · NCT07181564

• Combining Ketamine and Magnesium for Pain Relief After Nose Surgery

  This study is testing whether combining ketamine and magnesium during nose surgery can help reduce pain and lower the need for opioids afterward.

  Recruiting Ain Shams University · Cairo · NCT06966518

• Impact of Magnesium Sulfate on Nerve Monitoring During Surgery

  This study is testing if giving magnesium sulfate during spine and brain surgeries can improve nerve monitoring and pain management compared to a placebo.

  Recruiting Phase 4 Loma Linda University · Loma Linda, California · NCT04938765

• Antenatal magnesium sulphate to lower the risk of cerebral palsy in preterm babies

  It tests whether giving pregnant people at high risk of delivering between 32 and 35 weeks an IV dose of magnesium sulphate before birth can lower their baby's chance of cerebral palsy without causing significant harm to mother or baby.

  Recruiting Phase 3 Cairo University · Ismailia, Ismailia Governorate · NCT07524972

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.