Effects of Magnesium on Neuromuscular Transmission During Anesthesia
Interaction Between Intravenous Magnesium Sulfate and Volatile Anesthetics Compared to Propofol. A Three-center Prospective Randomized Single-blinded Electrophysiological Study
This study tests if giving magnesium during anesthesia can improve muscle relaxation for patients having elective surgeries that last at least an hour.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 96 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | University Hospital, Geneva Academic / other |
| Locations | 1 site (Sion) |
| Trial ID | NCT05261516 on ClinicalTrials.gov |
What this trial studies
This study investigates how intravenous magnesium sulfate affects neuromuscular transmission in patients undergoing general anesthesia with volatile anesthetics like desflurane, sevoflurane, and isoflurane. Using the TetraGraph device, the research aims to quantify the impact of magnesium on neuromuscular function compared to intravenous anesthesia with propofol. The study focuses on patients scheduled for elective surgeries lasting at least 60 minutes and evaluates the potential enhancement of muscle relaxant effects by magnesium. This systematic approach has not been previously explored in detail.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 65 with ASA status I or II, scheduled for elective surgery lasting at least 60 minutes.
Not a fit: Patients requiring neuromuscular blockade for their surgery or those with contraindications to magnesium or volatile anesthetics will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve anesthesia management and patient safety by optimizing neuromuscular blockade during surgeries.
How similar studies have performed: While the effects of magnesium on neuromuscular transmission have been noted, this specific investigation into its interaction with volatile anesthetics is novel and has not been systematically studied before.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients, age 18 to 65 years inclusive * American Society of Anesthesiology \[ASA\] status I or II * Body mass index 19 - 30 kg/m2 * Patient scheduled for elective surgery lasting ≥ 60 minutes * Patient is able to read and understand the information sheet and to sign and date the consent form. * Negative urinary or serum pregnancy test (not applicable if status post hysterectomy or tubal ligation or menopausal woman) Exclusion Criteria: * Surgery with need for neuromuscular block * Contraindication for general anesthesia with laryngeal mask airway, such as gastro-oesophageal reflux. * Hypersensitivity or allergy to magnesium sulfate or propofol * Contraindication to volatile anesthetics such as malignant hyperthermia * Patients with neuromuscular disease * Patients receiving medications known to influence neuromuscular function (for instance, aminoglycosides or phenytoine) * Known electrolyte abnormalities (for instance, hypermagnesemia) * Atrioventricular heart block * Patients with magnesium treatment within 48 hours before start of study * Liver insufficiency (bilirubine \<1.5x, ALAT/ASAT\<2.5x the upper limit of normal value) * Renal insuffisancy (créatinine \<1.5x upper limit of normal value, clearance\<30ml/minute) * Patient having participated in any clinical trial within 30 days, inclusive, of signing the informed consent form of the current trial. * Pregnant or breast-feeding women.
Where this trial is running
Sion
- Department of Anesthesiology and Intensive Care, Valais Hospital — Sion, Switzerland (Recruiting)
Study contacts
- Study coordinator: Christoph Czarnetzki, MD, MBA
- Email: christoph.czarnetzki@hcuge.ch
- Phone: +41 091 8116664
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.