Effects of low flow oxygen on carbon dioxide levels in children during apnea
Effect of Different Low Flow Rates on Gas Exchange in Anesthetized Children During Apnea A Single Blinded Randomized Study
This study tests how different low flow rates of oxygen can help keep carbon dioxide levels safe in children who are under anesthesia and stop breathing for a short time.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 1 Year to 6 Years |
| Sex | All |
| Sponsor | Fayoum University Hospital Academic / other |
| Locations | 1 site (Al Fayyum, Faiyum Governorate) |
| Trial ID | NCT06659887 on ClinicalTrials.gov |
What this trial studies
This study investigates how different low flow rates of oxygen affect carbon dioxide accumulation in anesthetized children during a 3-minute apnea period. It aims to determine the optimal flow rate that minimizes the risk of hypoxia, which is particularly critical in younger patients. The study will involve routine preoperative assessments and the use of nasal cannulas for oxygen delivery. The findings could enhance safety protocols during anesthesia in pediatric patients.
Who should consider this trial
Good fit: Ideal candidates are children aged 1 to 6 years, weighing between 10-20 kg, who are scheduled for elective surgery under general anesthesia.
Not a fit: Patients with respiratory diseases, anemia, or those requiring nasal intubation will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the safety of anesthesia in children by optimizing oxygen delivery during critical apnea periods.
How similar studies have performed: While studies on apneic oxygenation in adults have shown success, this specific approach in pediatrics is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Children aged 1 to 6 years old weighting 10-20 kg. * American Society of Anesthesiologists (ASA) physical status I or II. * Children will be scheduled for elective surgery under general anesthesia. Exclusion Criteria: * Parent refusal * Patient required nasal intubation * Children with a cardio-respiratory disease like asthma or recent upper respiratory infection. * Anemia. * Obstructive sleep apnea, sepsis. * Children prone to hypoxia or hypercarbia, and upper airway obstruction. * Children reported to have nasal obstruction .
Where this trial is running
Al Fayyum, Faiyum Governorate
- Fayoum University Hospital — Al Fayyum, Faiyum Governorate, Egypt (Recruiting)
Study contacts
- Study coordinator: Maha A Mohamed, M.Sc
- Email: mam56@fayoum.edu.eg
- Phone: 01061853735
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.