Effects of low-dose esmolol on heart injury in elderly patients after surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the relationship between preoperative frailty and myocardial injury in elderly patients undergoing non-cardiac surgery. It aims to identify predictive factors for myocardial injury and evaluate the impact of low-dose esmolol on reducing such injuries. Esmolol, a selective β-adrenergic receptor blocker, is administered to manage heart rate and reduce myocardial oxygen consumption during the perioperative period. The study will compare outcomes between patients receiving esmolol and those receiving a placebo.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥ 65 years;
2. ASA: ⅰ-ⅳ;
3. Modified frailty index (mFI) ≥ 0.21;
4. Patients undergoing non-cardiac surgery.

Exclusion Criteria:

1. Refuse to participate;
2. Expected hospital stay \<3 days;
3. Preoperative β-blocker therapy;
4. History of myocardial infarction or coronary artery disease;
5. Preoperative bradycardia (heart rate \[HR\] \< 50 bpm) or arrhythmia;
6. Significant cardiac insufficiency (i.e., pulmonary artery pressure \>18 mm Hg, cardiac index ≤ 2.2 L/min/m 2);
7. Severe valvular heart disease;
8. Severe lung disease (e.g. asthma or chronic obstructive pulmonary disease);
9. Patients with perioperative troponin elevation due to nonischemic causes (e.g., sepsis, pulmonary embolism, arrhythmia);
10. The same patient can only be included once, regardless of whether the reason for the second operation is related to the first cause.

    \-

Where it's running

• Qianfoshan Hospital, The First Hospital affiliated of Shandong First Medical University
  Jinan, Shandong, China Recruiting

Study contacts

• Study coordinator: yongtao Sun, PH.D
• Email: sunyongtao1979@163.com
• Phone: 18660795201

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Postprandial drop and frailty in older adults having planned noncardiac surgery

  This study tests whether a drop in blood pressure after meals and frailty predict low blood pressure after anesthesia starts in adults 65 and older undergoing planned noncardiac surgery.

  Recruiting Konya City Hospital · Konya, Konya · NCT07914920

• Frailty Training for Emergency Nurses in Morocco

  This trial tests whether a four-module training program helps Moroccan emergency nurses recognize and care for frail older adults in the ER.

  Recruiting Cadi Ayyad University · Safi, SAFI · NCT07892612

• Physical Function and Fall Risk in Older Adults in Lalín's Frailty Prevention Program

  This study will look at how physical function and fall risk change in people 70 and older who participate in a routine frailty and falls prevention program, by comparing assessments before and after the 8–12 week program.

  Recruiting University of Vigo · Lalín, Pontevedra · NCT07848802

• Esmolol vs Dexmedetomidine for opioid-sparing in laparoscopic gynecologic surgery

  This study tests whether low-dose esmolol or dexmedetomidine, given during surgery, reduces opioid use and improves pain control after laparoscopic hysterectomy compared with placebo.

  Recruiting National and Kapodistrian University of Athens · Athens · NCT07846722

• Home-based multicomponent exercise program for older adults with osteosarcopenia and frailty

  This study tests a home-based exercise program built on the Fogg Behavior Model to see if it improves frailty, muscle strength, physical function, bone density, and quality of life in adults aged 60–85 with osteosarcopenia and frailty.

  Recruiting at 2 sites Affiliated 2 Hospital of Nantong University · Nantong, Jiangsu and 1 other locations · NCT07845656

• VIVI-OLIVE: Multicomponent Exercise and Olive Oil for Older Adults at High Risk of Falls

  In adults 75 and older at high risk of falling, this study tests whether a 24-month plan of personalized exercise, Mediterranean diet guidance, and 60 mL of extra virgin olive oil daily can improve walking speed and reduce fall risk.

  Recruiting Fundacion Miguel Servet · Pamplona, Navarre · NCT07829484

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.