Effects of Lifelong Physical Activity on Aging and Immune Function

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how lifelong physical activity influences vitality capacity in older adults, focusing on neuromuscular function, metabolism, and immune response. Forty healthy participants over the age of 55 will be divided into two groups: those who have maintained regular physical activity for the past 30 years and those who have not. The study aims to assess differences in vitality capacity, particularly examining the role of T cell metabolism in relation to physical activity history. Participants will undergo comprehensive testing to evaluate their physical and immune health.

Why it matters

Who can join: the full rules

* General Inclusion Criteria:
* Men and women \> 55 years old
* Participants who are non-smokers or have been weaned for more than 3 years
* Menopausal women (confirmed for at least 6 months)
* Participants affiliated to the social security system
* Signature of informed consent
* Inclusion Criteria for the active population:
* Any person with structured aerobic physical activity (mainly involving cardiorespiratory function) on at least 3 days/week over the last 30 years without an interruption of more than 1 week in the 3 months preceding the study and without an interruption of more than 12 consecutive months over the last 30 years, as assessed by an interview conducted by an investigator specialising in physical activity;
* have a level of physical activity that meets the recommendations for physical activity in terms of the duration and intensity of weekly cardiorespiratory effort (WHO, 2020; ANSES, 2016) according to the criteria assessed by the GPAQ: at least 150 to 300 minutes per week of moderate-intensity aerobic activity (e.g., 5 days of moderate intensity activity of at least 30 minutes/day) or at least 75 to 150 minutes of sustained intensity endurance activity (e.g., 3 days of sustained activity of 25 minutes/day); or an equivalent combination of moderate and sustained intensity activities throughout the week.
* Inclusion criteria for the inactive population :
* Any person who does not meet the criteria for inclusion in the 'active' population defined above;
* Any person who has or has had a low physical intensity professional activity over the last 30 years: sedentary professional activity (work time generally spent in a seated position, such as office work) and/or a standing professional activity (work time spent standing or walking, without intense physical effort (e.g. shop assistant, hairdresser, caretaker, etc.).
* Anyone who does not practise or has not practised sport, fitness or other physical leisure activities alone or under supervision over the last 30 years, or who practises or has practised, over the last 30 years, a sport, fitness or other physical leisure activity less than or equal to 2 days a week and for a weekly period not exceeding 75 minutes.
* Anyone whose active mode of transport (cycling, walking) does not exceed an overall duration of 75 minutes per week, and whose consecutive time slots per journey are less than 10 minutes.
* Non-inclusion Criteria:
* Person suffering from a chronic illness
* Anyone who has used performance-enhancing drugs
* Anyone with a disability
* Person on medication
* Recent hospitalisation (within the last 6 months)
* People with osteoarthritis.
* Anyone who has had a cardiovascular event in the last 30 years (angina, heart attack)
* People with a current clinical acute inflammatory condition.
* People who have practised sport with known vascular complications.
* Persons under guardianship or trusteeship
* Exclusion Criteria: withdraw of consent

Where it's running

• CHU de Nice
  Nice, France Recruiting

Study contacts

• Principal investigator: Olivier GUERIN, MD — Centre Hospitalier Universitaire de Nice
• Study coordinator: Anne-Sophie Rousseau, PU
• Email: anne-sophie.rousseau@univ-cotedazur.fr
• Phone: 06,83,52,26,73

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Aquatic power training dosing strategies and creatine in older adults

  This trial tests whether different aquatic power training dosing methods and creatine supplementation help improve function in community-dwelling adults aged 60 and older.

  Recruiting University of Valencia · Valencia, Valencia · NCT07914270

• Intergenerational Interaction Program for Nursing Home Residents and Nursing Students

  A 6-week program pairs nursing home residents with nursing students to see if weekly joint activities can increase joy and reduce loneliness for older adults and lessen ageism in students.

  Recruiting Acibadem University · Istanbul · NCT07904299

• Supplemental Mobility for older adults in skilled nursing facilities

  This pilot tests whether adding a mobility aide to support walking and transfers alongside regular rehab helps older adults in SNFs after hospitalization see more daily activity and safer mobility.

  Recruiting University of Colorado, Denver · Aurora, Colorado and 1 other locations · NCT07872384

• Smart Voice Platform to Support Quality of Life for Community-Living Older Adults

  A smart voice platform is tested to see if it improves quality of life and healthy aging for older adults living in the community.

  Recruiting National Health Research Institutes, Taiwan · Taipei · NCT07855874

• Digital STEADI: A home-based digital fall prevention program for older adults

  A home-based digital program using AI-driven conversational agents tests if a guided fall-prevention exercise plan can reduce fall risk for older adults with mild cognitive impairment living independently.

  Recruiting Phase 1/2 Friendi.fi Corporation · Atlanta, Georgia · NCT07852650

• Sex hormones, menopause, and exercise in aging women

  This study tests how hormonal status and resistance training affect age-related muscle and nerve function in postmenopausal women.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT07848438

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.