Effects of Lactobacillus plantarum on fat and hormones in obese women
Official title: Lactobacillus Plantarum Lp90 and Hormonal Regulation in Obese Women：A Randomized, Double-Blind, Placebo-Controlled Trial
Run by Wecare Probiotics Co., Ltd. · NCT06987279 · Data updated 2026-11-12
This study tests if a daily probiotic called Lactobacillus plantarum can help reduce belly fat and balance hormones in obese women.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 40 Years |
| Sex | Women only |
| Enrollment | 100 (estimated) |
| Sponsor | Wecare Probiotics Co., Ltd. Industry-sponsored |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Zhengzhou, Henan) |
| Status | Recruiting |
| Started | June 10, 2025 |
| Main results expected | September 10, 2025 |
| Study ends | December 10, 2025 |
| Registry record updated | May 23, 2025 |
| Trial ID | NCT06987279 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women aged 18 to 40 with a BMI of 25 or higher who are willing to participate in follow-up and provide biological samples.
✕Probably not a fit
Patients with gastrointestinal diseases or severe neurological disorders may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates how the Lactobacillus plantarum Lp90 probiotic formula influences visceral fat metabolism and hormonal balance in obese women. Participants will be required to take the probiotic daily and provide blood, urine, and fecal samples for analysis. The study aims to understand the potential benefits of probiotics in managing obesity and related hormonal issues.
Why it matters
Potential benefit: If successful, this could provide a novel approach to managing obesity and improving hormonal balance in women.
How similar studies have gone: While the specific approach of using Lactobacillus plantarum for obesity management is relatively novel, other studies have shown probiotics can positively impact metabolic health.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age: 18 to 40 years old, female, BMI ≥ 25 kg/m2. 2. Be willing to receive follow-up during the intervention period. 3. Be willing to provide two blood, urine and fecal samples during the intervention period. 4. Be willing to take the compound probiotics by oneself every day during the intervention period. 5. Have good hearing and be able to hear and understand all instructions during the intervention period. \- Exclusion Criteria: 1. Suffering from digestive system diseases, mainly gastrointestinal diseases (celiac disease, ulcerative colitis, Crohn's disease). 2. Suffering from severe neurological disorders (epilepsy, stroke, severe head trauma, meningitis within the past 10 years, brain surgery, brain tumor, long-term coma - excluding general anesthesia). 3. Have received/are currently receiving treatment for the following mental illnesses: alcohol/drug/substance abuse dependence, schizophrenia, psychosis, bipolar disorder. 4. Take medication for depression or low mood. 5. Suffering from internal organ failure (such as heart, liver or kidney failure, etc.). 6. Have received radiotherapy or chemotherapy in the past. 7. Have received general anesthesia surgery/procedures within the past three years, or plan to receive general anesthesia procedures/surgeries within the next three months during this trial. 8. Have suffered from hepatitis (hepatitis B, hepatitis C), HIV or syphilis in the past. \-
Where it's running
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Fuwai Central-China Cardiovascular Hospital
Zhengzhou, Henan, China Recruiting
Study contacts
- Study coordinator: Yingpeng Tian, Doctor
- Email: tianyingpeng2021@163.com
- Phone: 13671979116
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.