Effects of ketone supplements on hormone levels after exercise in young men

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how taking exogenous ketone monoester supplements affects hormone levels in healthy young adult males following resistance exercise. Using a randomized, double-blind, placebo-controlled, within-subject crossover design, participants will undergo two treatment phases: one with the ketone supplement and one with a placebo. Blood samples will be collected at various time points to measure changes in hormones like testosterone and insulin after exercise. The study aims to understand the nutritional impact on hormonal responses during recovery from resistance training.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy adult male participants who are 18-40 years of age (inclusive).
* BMI \>18.5 and \<30.0 kg/m2
* Recreationally active (at least of 150 minutes of activity/week).
* Has maintained stable use of medication and supplements (which are not limited by the exclusion criteria), stable dietary and lifestyle habits, and stable body weight, for the last 3 months prior to screening and agree to maintain them throughout the study.
* Be willing to entirely avoid alcohol consumption 48 hours prior to the test days.
* Willing and able to agree to the requirements and restrictions of this study, be willing to give voluntary consent, be able to understand and read the questionnaires, and carry out all study-related procedures.

Exclusion Criteria:

* Individuals with metabolic disorders including: Type I or Type II diabetes.
* Individuals with a history of thrombosis / cardiovascular disease, endocrine disorders
* Individuals with knee injuries (i.e., ACL injuries).
* Individuals with a positive medical history of unstable thyroid disease (i.e., hypothyroidism, hyperthyroidism, hyperparathyroidism, and hypoparathyroidism) and immune disorders.
* Individuals who have used tobacco products within the last 6 months.
* Chronic usage of medications known to modulate hormone levels (i.e. corticosteroids and hormone replacement therapy (HRT)) in the last 6 months.
* Current use of ketone supplements or adherence to a ketogenic diet.
* Formal or regular weightlifting activity within the last year.

Where it's running

• McGill University
  Montreal, Quebec, Canada Recruiting
• McGill University
  Montreal, Quebec, Canada Not yet recruiting

Study contacts

• Principal investigator: Tyler Churchward-Venne, PhD — Department of Kinesiology and Physical Education, McGill University
• Study coordinator: Tyler A. Churchward-Venne, Ph.D.
• Email: tyler.churchward-venne@mcgill.ca
• Phone: (514) 399-9684

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.