Effects of ketone supplements on brain blood flow and cognition
The Acute Effects of a High Versus Low Dose of a Ketone Monoester Supplement on Cerebral Blood Flow and Cognition
This study is testing whether different amounts of a ketone supplement can improve brain blood flow and thinking skills in young adults.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 35 Years |
| Sex | All |
| Sponsor | McMaster University Academic / other |
| Locations | 1 site (Hamilton, Ontario) |
| Trial ID | NCT06032156 on ClinicalTrials.gov |
What this trial studies
This study investigates how different doses of an oral ketone supplement affect cerebral blood flow and cognitive function in young adults. Participants will receive either a low dose, a high dose, or a placebo of beta-hydroxybutyrate (β-OHB) to assess the dose-dependent effects on brain activity and related blood markers. The research aims to provide insights into the potential benefits of ketone bodies as an alternative energy source for the brain, especially during periods of fasting or low carbohydrate intake.
Who should consider this trial
Good fit: Ideal candidates are healthy young adults aged 18 to 35 without obesity or metabolic disorders.
Not a fit: Patients with obesity, cardiovascular disease, or those currently following a ketogenic diet may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new dietary strategies for enhancing cognitive function and brain health.
How similar studies have performed: While early evidence suggests potential benefits of ketone supplements, this specific dose-dependent approach is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: - Between the ages of 18 and 35 Exclusion Criteria: * Presence of obesity (body mass index \> 30 kg/m\^2) * Presence of known cardiovascular disease * Presence of type 2 diabetes * History of cardiovascular events requiring hospitalization (i.e., heart attack) * History of concussion(s) with persistent symptoms * Currently following a ketogenic diet and/or taking ketone body supplements
Where this trial is running
Hamilton, Ontario
- McMaster University — Hamilton, Ontario, Canada (Recruiting)
Study contacts
- Principal investigator: Jeremy J Walsh, PhD — McMaster University
- Study coordinator: Jeremy J Walsh, PhD
- Email: walshj18@mcmaster.ca
- Phone: 905-525-9140
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.