Effects of ketone esters on heart function in heart failure patients
Physiological Effects of Dietary Supplement Ketone Ester on the Heart
NA · The Cleveland Clinic · NCT05924802
This study tests whether ketone esters can improve heart function in people with heart failure by comparing them to a placebo over 12 weeks.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | The Cleveland Clinic (other) |
| Locations | 1 site (Cleveland, Ohio) |
| Trial ID | NCT05924802 on ClinicalTrials.gov |
What this trial studies
This study investigates the physiological effects of ketone esters on patients with heart failure by utilizing cardiac MRI for detailed imaging. Participants will be randomly assigned to receive either ketone esters or a placebo over a 12-week period. The primary goal is to assess changes in heart function and structure through advanced imaging techniques. This approach aims to provide insights into the potential therapeutic benefits of ketone esters in managing heart failure.
Who should consider this trial
Good fit: Ideal candidates for this study are patients diagnosed with heart failure and an ejection fraction of less than 40%.
Not a fit: Patients with claustrophobia or those with contraindicated implanted devices will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new dietary or therapeutic strategies for improving heart function in patients with heart failure.
How similar studies have performed: While the use of ketone esters in heart failure is a relatively novel approach, preliminary studies in related areas suggest potential benefits, though this specific application is less explored.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * heart failure EF \< 40% Exclusion Criteria: * Claustrophobia * Contraindicated implanted device
Where this trial is running
Cleveland, Ohio
- Cardiovascular Innovation Research Center — Cleveland, Ohio, United States (RECRUITING)
Study contacts
- Study coordinator: Christopher Nguyen, PhD
- Email: circ@ccf.org
- Phone: 2166365819
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Heart Failure