Effects of Ketone Ester on Salt Intake in Young Adults
Ketone Supplementation as a Strategy to Reduce the Negative Health Effects of High Dietary Salt in Young Adults
This study tests if ketone supplements can help young adults who eat a lot of salt protect their heart health and lower blood pressure.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 35 (estimated) |
| Ages | 19 Years to 39 Years |
| Sex | All |
| Sponsor | Indiana University Academic / other |
| Locations | 2 sites (Auburn, Alabama and 1 other locations) |
| Trial ID | NCT05545501 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of ketone supplements on cardiovascular health in young adults consuming high levels of dietary salt. It aims to understand how β-hydroxybutyrate, a ketone body, can counteract the negative effects of excessive salt intake, which is linked to hypertension and cardiovascular disease. Participants will be assigned to different dietary salt and ketone supplementation conditions to assess changes in blood pressure and vascular function. The study focuses on a population that is typically healthy but may be at risk due to high salt consumption.
Who should consider this trial
Good fit: Ideal candidates are healthy young adults aged 18-39 with normal blood pressure and a BMI below 35.
Not a fit: Patients with existing cardiovascular disease, diabetes, or obesity may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a novel dietary intervention to improve cardiovascular health in individuals with high salt intake.
How similar studies have performed: While there is limited evidence on the effects of ketone supplements in humans, some animal studies suggest potential benefits, making this approach relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Between the ages of 19-39 * Resting blood pressure no higher than 150/90 * BMI below 35 kg/m2 (or otherwise healthy) * Free of any metabolic disease (diabetes or renal), pulmonary disorders (COPD, severe asthma, \& cystic fibrosis), cardiovascular disease (peripheral vascular, cardiac, or cerebrovascular) * Do not have any precluding medical conditions that prevent participants from exercising (i.e., cardiovascular issues, or muscle/joint issues including painful arthritis) or giving blood (e.g., blood thinners). Exclusion Criteria: * High blood pressure - greater than 150/90 mmHg * Obesity (BMI \> 30 kg/m2) * History of metabolic disease (diabetes or renal disease), pulmonary disorders (e.g., COPD, severe asthma, \& cystic fibrosis), and cardiovascular disease (peripheral vascular, cardiac, or cerebrovascular). * Medical issues that prevent safe exercise (i.e., cardiovascular issues, or muscle/joint issues including painful arthritis) * Medical issues that prevent giving blood (e.g., blood thinners). * Current smoking, using smokeless tobacco, or vaping (within past 12 months) * Current pregnancy
Where this trial is running
Auburn, Alabama and 1 other locations
- Auburn University — Auburn, Alabama, United States (Completed)
- Indiana University, School of Public Health — Bloomington, Indiana, United States (Recruiting)
Study contacts
- Principal investigator: Austin T Robinson, PhD — Indiana University
- Study coordinator: Austin T Robinson, PhD
- Email: ausrobin@iu.edu
- Phone: 15745141034
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.