Effects of Ketone Ester on Salt Intake in Young Adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of ketone supplements on cardiovascular health in young adults consuming high levels of dietary salt. It aims to understand how β-hydroxybutyrate, a ketone body, can counteract the negative effects of excessive salt intake, which is linked to hypertension and cardiovascular disease. Participants will be assigned to different dietary salt and ketone supplementation conditions to assess changes in blood pressure and vascular function. The study focuses on a population that is typically healthy but may be at risk due to high salt consumption.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Between the ages of 19-39
* Resting blood pressure no higher than 150/90
* BMI below 35 kg/m2 (or otherwise healthy)
* Free of any metabolic disease (diabetes or renal), pulmonary disorders (COPD, severe asthma, \& cystic fibrosis), cardiovascular disease (peripheral vascular, cardiac, or cerebrovascular)
* Do not have any precluding medical conditions that prevent participants from exercising (i.e., cardiovascular issues, or muscle/joint issues including painful arthritis) or giving blood (e.g., blood thinners).

Exclusion Criteria:

* High blood pressure - greater than 150/90 mmHg
* Obesity (BMI \> 30 kg/m2)
* History of metabolic disease (diabetes or renal disease), pulmonary disorders (e.g., COPD, severe asthma, \& cystic fibrosis), and cardiovascular disease (peripheral vascular, cardiac, or cerebrovascular).
* Medical issues that prevent safe exercise (i.e., cardiovascular issues, or muscle/joint issues including painful arthritis)
* Medical issues that prevent giving blood (e.g., blood thinners).
* Current smoking, using smokeless tobacco, or vaping (within past 12 months)
* Current pregnancy

Where it's running

• Indiana University, School of Public Health
  Bloomington, Indiana, United States Recruiting

Study contacts

• Principal investigator: Austin T Robinson, PhD — Indiana University
• Study coordinator: Austin T Robinson, PhD
• Email: ausrobin@iu.edu
• Phone: 5745141034

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Using ketone supplements to manage salt intake effects in older adults

  This study is testing if ketone supplements can help older adults manage the harmful effects of a high-salt diet on their heart health and blood pressure.

  Recruiting Indiana University · Bloomington, Indiana · NCT06868719

• Using low-dose aspirin after preeclampsia to improve recovery

  This study is testing if taking low-dose aspirin for six months after having preeclampsia can help new moms recover better by improving their blood pressure and blood vessel function.

  Recruiting Phase 4 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT06281665

• IMB-guided health education to boost medication taking and blood pressure control in adults with hypertension

  This study tests a health-literacy program based on Information-Motivation-Behavioral Skills to help adults with hypertension who don’t take their medicines regularly to take them more consistently and better control their blood pressure.

  Recruiting at 8 sites Bahir Dar University · Ādēt and 7 other locations · NCT07894068

• Renal Nerve Stimulation to Help Blood Pressure in AF and HFpEF

  This study tests whether stimulating the kidneys with a catheter can safely lower blood pressure in adults with atrial fibrillation and HFpEF who also have hypertension.

  Recruiting London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · London, Ontario · NCT07893821

• Hypertension: Does Education Help Patients Manage Blood Pressure Better?

  This study tests whether structured patient education improves blood pressure control and self-management in adults with hypertension who speak Turkish.

  Recruiting Inonu University · Batman, Center · NCT07890090

• High BMI and periodontitis in Thai adults under 60

  This study tests how common high BMI and periodontitis are among Thai adults aged 18–59 and what factors are linked to them.

  Recruiting Mahidol University · Bangkok, Ratchathewi · NCT07880717

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.