Effects of Isometric Exercise on Kidney Blood Flow and Oxygenation
Cardio and Renovascular Effects of Static Muscle Work in the Healthy Human - Measured With Finapres® and Positron Emission Tomography (PET) Using 15-oxygen Labeled Water as Tracer Compared to Magnetic Resonance (MR)
This study is testing if isometric exercise can change blood flow and oxygen levels in the kidneys of healthy men to find the best way to check kidney health.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 10 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | Male |
| Sponsor | Bispebjerg Hospital Academic / other |
| Locations | 1 site (Copenhagen, Capital Region) |
| Trial ID | NCT06555211 on ClinicalTrials.gov |
What this trial studies
This randomized crossover study aims to validate renal perfusion measurements in healthy males using PET/CT with 15-oxygen labeled water as a tracer, compared to multiparametric MRI techniques. Participants will undergo both imaging methods to assess total renal blood flow, regional renal perfusion, oxygenation, and oxygen extraction at baseline and during isometric muscle exercise of the upper arm. The study will involve ten healthy male participants aged 20-60, who will follow a controlled diet and undergo multiple measurements over a single study day. The goal is to establish a reliable imaging technique for evaluating kidney vascular health.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy males aged 20-60 with no significant medical history affecting kidney function.
Not a fit: Patients with existing kidney disease, liver disease, or those on immunosuppressive treatments will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a non-invasive method for assessing kidney vascular health and damage in various renal diseases.
How similar studies have performed: While the use of PET/CT for renal perfusion is established, this specific validation against MRI techniques is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Normal health stated through medical questionnaire, examination and blood samples. Exclusion Criteria: * Immunosuppressive treatment * Alcohol abuse * Treatment with glucocorticoids, Glucagon-like peptide-1 (GLP-1) agonists, dipeptidyl peptidase 4 (DPP-4)-inhibitors * Medical treatment affecting insulin secretion or cardiovascular endpoints * Liver disease * Decreased kidney function * Severe claustrophobia * Elements incompatible with MR.
Where this trial is running
Copenhagen, Capital Region
- Bispebjerg Hospital, Department of Clinical Physiology & Nuclear Medicine — Copenhagen, Capital Region, Denmark (Recruiting)
Study contacts
- Principal investigator: Ali Asmar, MD, PhD — Bispebjerg Hospital, Department of Clinical Physiology and Nuclear Medicine
- Study coordinator: Peter Sørensen, MD
- Email: peter.soerensen@regionh.dk
- Phone: +4530516279
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.