Effects of hormone therapy and exercise on health in postmenopausal women
Official title: De Invloed Van Hormoonsubstitutietherapie en Gesuperviseerde Training op Lichaamssamenstelling, Cardiovasculair Risico en Insulinegevoeligheid Bij Postmenopauzale Vrouwen
Run by University Hospital, Ghent · NCT05831709 · Data updated 2026-11-12
This study tests if combining exercise with hormone therapy can improve health markers in postmenopausal women.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 45 Years to 65 Years |
| Sex | Women only |
| Enrollment | 390 (estimated) |
| Sponsor | University Hospital, Ghent Academic / other |
| Locations | 1 site (Ghent) |
| Status | Recruiting |
| Started | May 12, 2023 |
| Main results expected | December 31, 2027 |
| Study ends | December 2028 |
| Registry record updated | November 18, 2025 |
| Trial ID | NCT05831709 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are postmenopausal women in good general health with a BMI between 20 and 30 kg/m2.
✕Probably not a fit
Patients who are not yet in menopause or have a BMI outside the range of 20-30 kg/m2 may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This trial investigates the combined effects of supervised exercise training and hormone replacement therapy on various health outcomes in postmenopausal women. A total of 270 participants will engage in a structured exercise program lasting between 12 to 24 weeks. The study aims to assess changes in body composition, cardiovascular risk, insulin sensitivity, and other health markers. By focusing on this specific demographic, the trial seeks to provide insights into effective interventions for improving health in postmenopausal women.
Why it matters
Potential benefit: If successful, this study could lead to improved health outcomes and quality of life for postmenopausal women.
How similar studies have gone: Other studies have shown promising results with similar approaches combining exercise and hormone therapy in improving health outcomes for postmenopausal women.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Postmenopausal women (diagnosed by physician) with complaints due to menopause * Indication for hormonal substitution therapy (except for the control group) * Good general health * BMI: 20-30 kg/m2 * Only the use of cholesterol-, blood pressure- or/and thyroid-regulating medication is permitted
Where it's running
-
Ghent University Hospital - Women's Clinic
Ghent, Belgium Recruiting
Study contacts
- Study coordinator: Herman Depypere
- Email: studieco.vrouwenkliniek@uzgent.be
- Phone: 003293323783
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Hop extract vs soy isoflavone for menopausal symptoms
This study tests whether a full-spectrum hop extract helps reduce menopausal mood symptoms better than soy isoflavones in peri- and postmenopausal women.
-
Plant extract supplement for menopausal symptoms in women around menopause
A plant-extract dietary supplement is being tested to see if it helps hot flashes and related symptoms in women aged 42–60 who are nearing or just past menopause, compared with a placebo.
-
Lifestyle changes to ease menopausal symptoms, sleep problems, and anxiety
Researchers are testing whether a structured lifestyle education program helps perimenopausal and postmenopausal women see fewer menopausal symptoms, better sleep, and less anxiety compared to usual care.
-
Dietary guidelines-based eating plan to reduce menopausal symptoms in overweight and obese women
A randomized trial will test whether following healthy eating guidance from Brazil’s dietary guidelines can lessen menopausal symptoms in women who are overweight or obese.
-
Effects of statins and hormone therapy on coagulation in menopausal women with high cholesterol
This study tests whether adding a statin to estrogen-progestin hormone therapy changes the blood’s clotting profile in menopausal women with high cholesterol who need hormone therapy.
-
Air program for perimenopause symptoms
A 24-week remote program called AIR is tested to see if it helps perimenopausal symptoms more than waiting list care.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.