Clinical trial Recruiting at 1 site Interventional Ages 45 to 65 Women only

Effects of hormone therapy and exercise on health in postmenopausal women

Official title: De Invloed Van Hormoonsubstitutietherapie en Gesuperviseerde Training op Lichaamssamenstelling, Cardiovasculair Risico en Insulinegevoeligheid Bij Postmenopauzale Vrouwen

Run by University Hospital, Ghent · NCT05831709 · Data updated 2026-11-12

This study tests if combining exercise with hormone therapy can improve health markers in postmenopausal women.

More Postmenopause trials

Quick facts

Study typeInterventional
Ages45 Years to 65 Years
SexWomen only
Enrollment390 (estimated)
SponsorUniversity Hospital, Ghent
Academic / other
Locations1 site (Ghent)
StatusRecruiting
StartedMay 12, 2023
Main results expectedDecember 31, 2027
Study endsDecember 2028
Registry record updatedNovember 18, 2025
Trial IDNCT05831709 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are postmenopausal women in good general health with a BMI between 20 and 30 kg/m2.

Probably not a fit

Patients who are not yet in menopause or have a BMI outside the range of 20-30 kg/m2 may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial investigates the combined effects of supervised exercise training and hormone replacement therapy on various health outcomes in postmenopausal women. A total of 270 participants will engage in a structured exercise program lasting between 12 to 24 weeks. The study aims to assess changes in body composition, cardiovascular risk, insulin sensitivity, and other health markers. By focusing on this specific demographic, the trial seeks to provide insights into effective interventions for improving health in postmenopausal women.

Why it matters

Potential benefit: If successful, this study could lead to improved health outcomes and quality of life for postmenopausal women.

How similar studies have gone: Other studies have shown promising results with similar approaches combining exercise and hormone therapy in improving health outcomes for postmenopausal women.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Postmenopausal women (diagnosed by physician) with complaints due to menopause
* Indication for hormonal substitution therapy (except for the control group)
* Good general health
* BMI: 20-30 kg/m2
* Only the use of cholesterol-, blood pressure- or/and thyroid-regulating medication is permitted

Where it's running

  • Ghent University Hospital - Women's Clinic
    Ghent, Belgium
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.