Effects of HMB supplementation on muscle recovery after knee surgery in female athletes
Influence of β-hydroxy β-methyl Butyrate (HMB)Supplementation on Post-operative Muscle Mass and Function in Female Athletes
This study is testing if a supplement called caHMB can help female athletes recover better and keep their muscle strength after knee surgery.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | Female |
| Sponsor | University of Kansas Medical Center Academic / other |
| Locations | 1 site (Overland Park, Kansas) |
| Trial ID | NCT05869812 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates the impact of calcium-β-hydroxy-β-methylbutyrate (caHMB) supplementation on muscle mass and function in female athletes recovering from anterior cruciate ligament (ACL) surgery. Participants will be randomly assigned to receive either caHMB or a placebo while following standard postoperative rehabilitation protocols. The study aims to assess changes in quadriceps and hamstring muscle size and function, leveraging the collaboration with orthopedic specialists at the University of Kansas Health System. The goal is to determine if caHMB can enhance recovery and reduce muscle atrophy during rehabilitation.
Who should consider this trial
Good fit: Ideal candidates are biological females aged 18 to 35 who are undergoing rehabilitation after ACL surgery.
Not a fit: Patients with recent nutritional supplement use or psychiatric conditions that may hinder recovery may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve recovery outcomes and muscle function in female athletes after knee surgery.
How similar studies have performed: Previous studies have shown that caHMB can improve muscle protein synthesis and reduce atrophy, indicating potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Participant has provided written and dated informed consent to participate in the study. 2. Participant is biological female between 18 and 45 years of age, inclusive. 3. Participant intends to complete postoperative rehabilitation at affiliated physical therapy clinic. Exclusion Criteria: 1. Participant is currently consuming nutritional supplements or has recently (regularly) consumed nutritional supplements, other than multivitamins and minerals in \<9 weeks prior to participation. 2. Participant currently suffers from a sleep disorder and/or has a known history of (or is currently being treated for) clinical depression, eating disorder(s) or any other psychiatric condition(s) that might limit natural recovery from substantial injury. 3. Participant has a history of orthopedic injury or surgery within the last year in the non-operative limb that may prevent them from completing the study procedures. 4. Participant has history of previous injury or surgery in the operative limb. 5. Participant has implants, hardware, devices, or other non-removable metal material in the body that would limit the accuracy of body composition assessments within the measurement area. 6. Participant is participating in another clinical trial or has received an investigational product within thirty days prior to enrollment. 7. Participant has a known allergy or sensitivity to any ingredient in the test product/s. 8. Participant is pregnant as confirmed by a urine sample and hCG test.
Where this trial is running
Overland Park, Kansas
- University of Kansas Health System — Overland Park, Kansas, United States (Recruiting)
Study contacts
- Study coordinator: Ashley Herda, PhD
- Email: a.herda@ku.edu
- Phone: 913-897-8618
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.