Effects of HMB supplementation on muscle recovery after knee surgery in female athletes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the impact of calcium-β-hydroxy-β-methylbutyrate (caHMB) supplementation on muscle mass and function in female athletes recovering from anterior cruciate ligament (ACL) surgery. Participants will be randomly assigned to receive either caHMB or a placebo while following standard postoperative rehabilitation protocols. The study aims to assess changes in quadriceps and hamstring muscle size and function, leveraging the collaboration with orthopedic specialists at the University of Kansas Health System. The goal is to determine if caHMB can enhance recovery and reduce muscle atrophy during rehabilitation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Participant has provided written and dated informed consent to participate in the study.
2. Participant is biological female between 18 and 45 years of age, inclusive.
3. Participant intends to complete postoperative rehabilitation at affiliated physical therapy clinic.

Exclusion Criteria:

1. Participant is currently consuming nutritional supplements or has recently (regularly) consumed nutritional supplements, other than multivitamins and minerals in \<9 weeks prior to participation.
2. Participant currently suffers from a sleep disorder and/or has a known history of (or is currently being treated for) clinical depression, eating disorder(s) or any other psychiatric condition(s) that might limit natural recovery from substantial injury.
3. Participant has a history of orthopedic injury or surgery within the last year in the non-operative limb that may prevent them from completing the study procedures.
4. Participant has history of previous injury or surgery in the operative limb.
5. Participant has implants, hardware, devices, or other non-removable metal material in the body that would limit the accuracy of body composition assessments within the measurement area.
6. Participant is participating in another clinical trial or has received an investigational product within thirty days prior to enrollment.
7. Participant has a known allergy or sensitivity to any ingredient in the test product/s.
8. Participant is pregnant as confirmed by a urine sample and hCG test.

Where it's running

• University of Kansas Health System
  Overland Park, Kansas, United States Recruiting

Study contacts

• Study coordinator: Ashley Herda, PhD
• Email: a.herda@ku.edu
• Phone: 913-897-8618

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.