Effects of grape powder on eye health and blood sugar in older adults
Impact of Regular Consumption of Grape on Eye Health and Regulation of Advanced Glycation End-products in Singapore Older Adults
This study is testing if eating freeze-dried grape powder can help improve eye health and blood sugar levels in older adults.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 46 (estimated) |
| Ages | 60 Years to 85 Years |
| Sex | All |
| Sponsor | National University of Singapore Academic / other |
| Locations | 1 site (Singapore) |
| Trial ID | NCT06349304 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of regular consumption of freeze-dried table grape powder on eye health and the regulation of advanced glycation end products in older adults in Singapore. It is a 16-week, double-blind, randomized, placebo-controlled trial involving 46 participants aged 60 to 85. Participants will be randomly assigned to either the grape powder or placebo group to assess improvements in eye health, glycemic status, and inflammation levels. The study includes multiple visits for screening and assessments throughout the trial period.
Who should consider this trial
Good fit: Ideal candidates are older adults aged 60 to 85 who are English-literate and can provide informed consent.
Not a fit: Patients with existing serious eye diseases, diabetes, or those on specific diets or medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to dietary recommendations that improve eye health and glycemic control in older adults.
How similar studies have performed: While there have been studies on dietary interventions for eye health, this specific approach using freeze-dried grape powder is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Male and female participants, aged between 60 and 85 years old inclusive 2. English-literate and able to give informed consent in English Exclusion Criteria: 1. Smokers 2. Allergy to grapes or food dyes/additives, or had serious food allergies in the past 3. Known eye diseases (macular degeneration, cataracts, retinopathy or glaucoma), blindness in at least one eye or have had eye surgery 4. Unable to view bright lights or flashing lights 5. Has Type 1 or 2 diabetes, uremia, cardiovascular disease, abnormal kidney and liver function 6. Taking eye medication and/or dietary supplements for the eyes for the past 3 month 7. Taking supplements containing carotenoids (e.g. Vitamin A, lutein, zeaxanthin) for past 3 months 8. Currently on a specialised diet (e.g. vegetarian, vegan, weight loss diet, low fat diet 9. Consumes more than 2 alcoholic drinks per day i.e. one drink is defined as either 150ml of wine,340ml of beer/cider or 45ml of distilled spirit 10. Significant change in weight (≥ 3 kg body weight) in the past 3 months 11. Significant exercise pattern over the past 3 months defined as high-intensity exercise of more than 3 hours per week 12. Currently on anti-hypertensive, cholesterol-lowering or psychoactive drugs 13. Scored ≤ 7 on the abbreviated mental test 14. Poor peripheral venous access based on past experiences with blood draw 15. Participating in another clinical study
Where this trial is running
Singapore
- National University of Singapore, Faculty of Science, Department of Food Science and Technology — Singapore, Singapore (Recruiting)
Study contacts
- Principal investigator: Jung Eun Kim, Ph.D., R.D. — National University of Singapore
- Study coordinator: Marcus Ting
- Email: marcusting@u.nus.edu
- Phone: 97851245
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.