Effects of GLP-1 and GIP/GLP-1 medications on diet, metabolism, and behavior in adults with excess weight

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will follow adults starting treatment with GLP-1 or GIP/GLP-1 analogues and collect data before treatment and at 3, 6, and 12 months. Researchers will measure weight, body composition, biochemical markers, and detailed dietary intake to capture both quantitative and qualitative changes in eating. The protocol also tracks appetite regulation, risk of malnutrition and muscle loss, and any adverse events to provide a holistic view of treatment effects. Data will be collected at four clinic visits at the Clinic of Diabetology and Internal Medicine, Medical University of Warsaw.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18-65 years,
* Diagnosed obesity (BMI ≥ 30 kg/m²) or overweight (BMI ≥ 27 kg/m²) with comorbidities associated with excess body weight (including type 2 diabetes, hypertension, dyslipidemia, obstructive sleep apnea, cardiovascular disease),
* Eligibility for treatment with GLP-1 or GIP/GLP-1 analogues,
* Not taking GLP-1 and GIP/GLP-1 analogue medications for at least one year prior to study enrollment,
* Ability to provide informed consent,
* Informed consent to participate in the study.

Exclusion Criteria:

* Age under 18 or over 65 years,
* Inability to qualify for treatment with GLP-1 and GIP/GLP-1 analogues,
* Pregnancy or breastfeeding,
* Diagnosed eating disorders,
* Active cancer or gastrointestinal conditions that may affect the absorption or tolerance of treatment (e.g., inflammatory bowel disease, conditions after extensive gastrointestinal resections, conditions after bariatric surgery),
* Inability to participate in regular follow-up visits,
* Inability to provide informed consent,
* Failure to provide informed consent to participate in the study.

Where it's running

• Klinika Diabetologii i Chorób Wewnętrznych Uniwersyteckiego Centrum Klinicznego Warszawskiego Uniwersytetu Medycznego
  Warsaw, Warszawa, Poland Recruiting

Study contacts

• Study coordinator: Leszek Czupryniak, professor
• Email: leszek.czupryniak@wum.edu.pl
• Phone: 602245254

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.