Effects of fluid infusion rates on blood circulation during surgery
The Impact of Intra-operative Fluid Infusion Rate on Hemodilution and Microcirculation Prospective Observational Pilot Study
NA · University Hospital Hradec Kralove · NCT05606536
This study tests how different rates of fluid given during surgery can improve blood flow and oxygen delivery to tissues for patients undergoing elective surgeries with little blood loss.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital Hradec Kralove (other) |
| Locations | 1 site (Hradec Králové) |
| Trial ID | NCT05606536 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of intraoperative fluid therapy on microcirculation during elective surgeries with minimal blood loss. It aims to optimize fluid infusion rates to enhance oxygen supply to tissues while minimizing hemodilution caused by endothelial glycocalyx damage. The research will analyze flow parameters in microcirculation based on different fluid infusion rates, providing insights into the optimal management of fluid therapy in surgical settings.
Who should consider this trial
Good fit: Ideal candidates include patients undergoing elective recumbent and laparoscopic surgeries with minimal expected blood loss.
Not a fit: Patients experiencing significant blood loss over 250 ml or those requiring hemodynamic support with noradrenaline will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved fluid management strategies during surgery, enhancing patient outcomes and recovery.
How similar studies have performed: While the approach of optimizing fluid therapy is established, the specific focus on microcirculation parameters related to infusion rates is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * elective recumbent and laparoscopic surgery * informed consent Exclusion Criteria: * blood loss over 250 ml * hemodynamic instability requiring noradrenaline infusion
Where this trial is running
Hradec Králové
- University Hospital Hradec Kralove — Hradec Králové, Czechia (RECRUITING)
Study contacts
- Study coordinator: David Astapenko, MD, PhD
- Email: david.astapenko@fnhk.cz
- Phone: +420495833218
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Fluid Therapy, Microcirculation, Hemodilution