Effects of fiber supplements on gut bacteria in the colon

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates how daily fiber supplementation influences the microbiome of the colonic mucosa over a 28-day period. Participants will take dietary fiber orally and may undergo standard procedures like proctoscopy or colonoscopy for assessment. The primary goal is to determine the impact of dietary fiber on the gut microbiome, which is crucial for preventing the development of precancerous polyps. Blood samples will also be collected for further analysis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \>= 18 years
* Ability to understand and the willingness to sign a written informed consent document
* Patients who present with a chief complaint of a benign anorectal pathology including hemorrhoids, anal fissures, and anal fistulas without underlying conditions such as colorectal cancer or Crohn's disease or are undergoing a standard of care colonoscopy procedure

Exclusion Criteria:

* Patients with an active malignancy, Crohn's disease, ulcerative colitis, and immunosuppressed patients
* Patients with hereditary colon cancer syndrome including Lynch syndrome or Familial Adenomatous Polyposis (FAP)
* Patients with a prior history of total or partial colon resection
* Colorectal pathology, such cancer or proctitis, after initial study scope

Where it's running

• OHSU Knight Cancer Institute
  Portland, Oregon, United States Recruiting

Study contacts

• Principal investigator: Vassiliki L Tsikitis, M.D. — OHSU Knight Cancer Institute
• Study coordinator: Shahrose Rahman, M.D.
• Email: rahmasha@ohsu.edu
• Phone: 503-494-8652

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.