Effects of fatty acids on metabolism in patients with a specific deficiency and healthy individuals
Official title: Metabolic Effects of Medium-Chain Fatty Acids in Patients With Medium-Chain Acyl-CoA Dehydrogenase Deficiency and Healthy Individuals
Run by University of Copenhagen · NCT06623032 · Data updated 2026-11-12
This study tests how different types of fatty acids affect metabolism in people with Medium-Chain Acyl-CoA Dehydrogenase Deficiency and healthy individuals.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | University of Copenhagen Academic / other |
| Locations | 1 site (Copenhagen) |
| Status | Recruiting |
| Started | October 18, 2024 |
| Main results expected | September 2027 |
| Study ends | September 2027 |
| Registry record updated | August 14, 2026 |
| Trial ID | NCT06623032 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include males and females aged 18-80 who have been diagnosed with Medium-Chain Acyl-CoA Dehydrogenase Deficiency.
✕Probably not a fit
Patients with diabetes, kidney or liver disease, or those on specific medications may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the physiological effects of medium-chain fatty acids (MCFA) and long-chain fatty acids (LCFA) in individuals diagnosed with Medium-Chain Acyl-CoA Dehydrogenase Deficiency (MCADD) and healthy participants. It employs a randomized crossover design with two test days, where participants will ingest either MCFA or LCFA in the form of triacylglycerol oils. The order of ingestion is randomized to assess the metabolic responses to each type of fatty acid. The study aims to provide insights into lipid metabolism and potential dietary recommendations for MCADD patients.
Why it matters
Potential benefit: If successful, this study could lead to improved dietary guidelines and management strategies for patients with MCADD.
How similar studies have gone: While there is limited data on similar studies, the investigation of fatty acid metabolism is a well-explored area, suggesting potential for meaningful insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria MCADD patients: * Male or female * Age between 18-80 years old * Diagnosed Medium-chain acyl-CoA dehydrogenase deficiency (MCADD Inclusion Criteria Healthy Participants: * Male or female * Age between 18-80 years old Exclusion Criteria both MCADD patients and healthy participants: * Diabetes * Kidney- or liver disease * Use of beta blockers or diuretics * Pregnant, lactating or planning to become pregnant within the study period * Regular intake of substantial amounts of coconut oil, palm kernel oil or any other source abundant in MCFA * Ongoing cancer treatment * Metabolic or absorptive disorders, gastric bypass operation, or use of medication affecting metabolism or food absorption * Inability, physically or mentally, to comply with the procedure required by the study protocol as evaluated by the primary investigator, study manager or clinical responsible
Where it's running
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University of Copenhagen
Copenhagen, Denmark Recruiting
Study contacts
- Principal investigator: Andreas M Fritzen, Associate Professor — University of Copenhagen
- Study coordinator: Kasper S Jørgensen, PhD student
- Email: kaspersuhr@sund.ku.dk
- Phone: +4523473023
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Treatment of Medium Chain Acyl-CoA Dehydrogenase Deficiency with Sodium Phenylbutyrate
This study is testing if sodium phenylbutyrate can safely help people aged 4 and older with medium-chain acyl-CoA dehydrogenase deficiency feel better.
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Natural history of MADD: what happens over time in people with this condition
This study follows people with MADD over time to see how the condition changes, what symptoms appear, and which biomarkers and patient-reported outcomes are meaningful.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.