Effects of exercise on muscle health in older adults
The Effects of Exercise Intervention on Skeletal Muscle and Other Organs in Aged Population and the Discovery of Associated Circulating Biomarkers
This study tests how exercise can improve muscle health in older adults aged 65 and up who have early physical challenges.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 65 Years and up |
| Sex | All |
| Sponsor | National Yang Ming Chiao Tung University Academic / other |
| Locations | 1 site (Taipei) |
| Trial ID | NCT06660706 on ClinicalTrials.gov |
What this trial studies
This project investigates how exercise impacts skeletal muscle and adipose tissue in older adults, focusing on the aging process. It employs a randomized controlled trial design with a 6-month multidomain intervention program for community-dwelling individuals aged 65 and older who exhibit early physical impairments. The study also examines blood samples to identify circulating biomarkers associated with muscle health and aging. By understanding the systemic effects of exercise, the research aims to develop strategies to counteract age-related functional decline.
Who should consider this trial
Good fit: Ideal candidates are community-dwelling adults aged 65 and older with slow gait speed or weakness.
Not a fit: Patients with established neurodegenerative diseases, severe mobility limitations, or acute illnesses may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance muscle health and overall well-being in the aging population, potentially leading to longer, healthier lives.
How similar studies have performed: Other studies have shown promising results in improving muscle health through exercise interventions in older adults, indicating that this approach is supported by existing research.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * aged ≥ 65 years * slow gait speed (\<1 m/s in 6-meter walk test) or weakness (dominant handgrip strength \<28 kg in men, \<18 kg in women) Exclusion Criteria: * established diagnosis of dementia, Parkinsonism or other mobility-limiting, disable conditions * active, acute diseases receiving treatment, such as cancer, heart failure, COPD and so on * estimated life expectancy \<12 months * current nursing home residents
Where this trial is running
Taipei
- Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University — Taipei, Taiwan (Recruiting)
Study contacts
- Principal investigator: Li-Ning Peng, M.D., PhD — Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University
- Study coordinator: Li-Ning Peng, M.D., PhD
- Email: lining.peng@gmail.com
- Phone: +886-28239014
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.