Effects of exercise on brain function in chronic cannabis users

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how acute exercise influences cognitive functions and blood markers related to brain plasticity in individuals who regularly use cannabis. It aims to compare the endocannabinoid system's response to exercise between chronic cannabis users and non-users. Participants will undergo activity tests to assess these effects, focusing on the relationship between exercise and neurogenesis. The study seeks to understand the potential benefits of exercise in modifying the effects of chronic cannabis use on brain health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Cannabis consumer group:

* Cannabis consumption \> 100 times in lifetime, last exposure \< 7 days, and recent exposure \> 10 times in the month.
* Positive toxicological urine test for ∆-9-THC.
* Having a cannabis use disorder according to the CAST.

Healthy group:

* Negative urine toxicological test for cannabis.
* No regular cannabis use for more than 6 months once in a lifetime.
* No cannabis consumption in the 6 months preceding the study.

Exclusion Criteria:

For all subjects :

* Disorders of use of other substances (alcohol, cocaine, opioid, or synthetic drugs).
* Alcohol consumption greater than 30g per day (averaged over one week) and/or alcohol abuse the week preceding the visit.
* Under medical treatment.
* Presence of diagnosed neurological disorders.
* Diagnosis of a psychotic picture entering axis I, DSM-5.
* Chronic progressive disease or in remission.
* Body mass index \> 30 kg/m2 (i.e. presence of obesity).

Where it's running

• CHU Lille
  Lille, France Recruiting

Study contacts

• Study coordinator: Olivier Cottencin, MD,PhD
• Email: olivier.cottencin@chru-lille.fr
• Phone: 0320445962

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.