Effects of exercise on aging and cognitive function
Ameliorating Effects of Aging by Physical Exercise: Molecular, Metabolic and Structural Adaptations, Multi-organ Integrative Approach
This study is testing whether regular exercise can help older adults with mild cognitive impairment improve their thinking and movement skills over time.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 120 (estimated) |
| Ages | 55 Years to 85 Years |
| Sex | All |
| Sponsor | Slovak Academy of Sciences Government |
| Locations | 1 site (Bratislava) |
| Trial ID | NCT05232968 on ClinicalTrials.gov |
What this trial studies
This interventional study investigates how regular physical exercise can influence cognitive and motor functions in seniors with mild cognitive impairment. Participants will engage in both short-term (4 months) and long-term (≥2 years) exercise programs to assess the impact on their health and aging processes. The study aims to explore the physiological mechanisms behind these effects, focusing on metabolism, motor skills, cognition, and bioactive molecules. Recruitment will be conducted by psychologists and neurologists in Bratislava, ensuring informed consent and ethical oversight.
Who should consider this trial
Good fit: Ideal candidates are seniors aged 55-85 with mild cognitive impairment who have led a sedentary lifestyle for at least two years.
Not a fit: Patients with chronic diseases or significant comorbidities that prevent participation in exercise programs may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to effective lifestyle interventions that delay the onset or progression of neurodegenerative diseases like Alzheimer's.
How similar studies have performed: Other studies have shown promising results in using exercise to improve cognitive function in older adults, suggesting this approach has potential.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 55-85 years of age, * non-smokers * complete vaccination against COVID19 * continuation in the supervised exercise program (for study of long-term effects of exercise experimental group) * sedentary lifestyle ≥2 years prior this study (for group without intervention), * mild cognitive impairment (for study of short-term effects of exercise experimental group) * absence of any psychological, sociological or geographical factor that could jeopardize participation in the project. Exclusion Criteria: * any chronic disease (oncological, cardiovascular, neurological, liver, kidney or other diseases and its acute complications at the discretion of the doctor); * no cooperation of probands; * insufficient functional capacity - the presence comorbidities or disorders of the musculoskeletal system, which makes it impossible to complete the training program (assessment by cardiologist, or orthopedist or other specialist); * smoking, alcohol or drugs abuse; * non-compliance with epidemiological measures; * absence of complete vaccination with SARS-CoV-2 vaccine; * presence of a pacemaker or metal implants (contraindication for magnetic resonance imaging).
Where this trial is running
Bratislava
- Biomedical Research Center Slovak Academy of Sciences — Bratislava, Slovakia (Recruiting)
Study contacts
- Principal investigator: Barbora Ukropcova, Prof. — Biomedical Research Center Slovak Academy of Sciences
- Study coordinator: Barbora Ukropcova, Prof.
- Email: barbara.ukropcova@sabva.sk
- Phone: +421911643630
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.