Effects of Esketamine on Recovery After Propofol Anesthesia
Effects of Esketamine on Recovery of Consciousness After Propofol Anesthesia
This study is testing if giving a low dose of esketamine can help people recover faster from anesthesia during a specific surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 150 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | Female |
| Sponsor | Beijing Tiantan Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Trial ID | NCT06430645 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates whether subanesthetic doses of esketamine can accelerate the recovery of consciousness in patients undergoing propofol anesthesia. It aims to understand the changes in brain networks when esketamine is administered during anesthesia. The study will involve patients aged 18 to 50 scheduled for elective operative hysteroscopy, comparing the effects of esketamine to a saline control. The trial will also assess the safety and efficacy of esketamine in this context.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 50 who are scheduled for elective operative hysteroscopy.
Not a fit: Patients with contraindications to propofol or esketamine, or those with significant comorbidities, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to faster recovery times for patients after anesthesia, improving overall surgical outcomes.
How similar studies have performed: While there have been studies on ketamine's effects on anesthesia recovery in animals, this specific approach in humans is novel and untested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged from 18 years to 50 years * Patients scheduled for elective operative hysteroscopy * Willing to sign informed consent Exclusion Criteria: * Contraindications of propofol and esketamine * Contraindications for EEG; * ASA≥III; * BMI≥30 kg/m2 or BMI\<18 kg/m2; * The MMSE scale score is lower than the normal value; * Alcohol or drug abuse; * Untreated or under-treated hypertension, hyperthyroidism, risk of increased intracranial pressure, audio-visual impairment, history of psychiatric disorders or neurological diseases, malignant tumors or other major diseases; * Use of other neurological drugs or drugs known to interact with propofol and esketamine in the past 2 weeks; * Pregnant and lactating women; * The operation duration is shorter than 15 minutes or longer than 60 minutes.
Where this trial is running
Beijing, Beijing Municipality
- Beijing Tiantan Hospital, Capital Medical University — Beijing, Beijing Municipality, China (Recruiting)
Study contacts
- Principal investigator: Ruquan Han, PhD — Beijing Tiantan Hospital
- Study coordinator: Yang Li, Master
- Email: liyang0519@mail.ccmu.edu.cn
- Phone: +86 18810637134
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.