Effects of eating durian on gut health and metabolism
Precision Nutrition - Impacts of Durian Consumption on Human Microbiome and Metabolome in Healthy Staff Volunteers From SingHealth
This study is testing whether eating durian every day can improve gut health and metabolism in healthy people.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 21 Years to 60 Years |
| Sex | All |
| Sponsor | National Cancer Centre, Singapore Academic / other |
| Locations | 1 site (Singapore) |
| Trial ID | NCT06194084 on ClinicalTrials.gov |
What this trial studies
This clinical study explores how daily consumption of durian affects the gut microbiome and metabolome in healthy individuals. Participants will undergo an initial low-fiber diet washout for 14 days, followed by a 1-week period of consuming 100 grams of durian pulp daily, then 200 grams daily for another week. Throughout the study, participants will maintain a low-fiber diet and record their stool consistency and frequency. Stool and blood samples will be collected at various time points to analyze the impact of durian on gut health and metabolic parameters.
Who should consider this trial
Good fit: Ideal candidates are healthy adults aged 21 to 60 who are willing to consume durian and maintain a low-fiber diet.
Not a fit: Patients with known allergies to durian or those with significant metabolic disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to personalized nutrition strategies that enhance gut health and metabolic outcomes.
How similar studies have performed: While there is limited research specifically on durian, studies on other dietary impacts on the microbiome have shown promising results, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Male and/or female subjects between the ages of 21 and 60 years, inclusive 2. Willing and able to provide written informed consent 3. Must be in generally good health with clinically insignificant screening results (Fasting plasma glucose level \& Lipid profile), as determined by the Investigator 4. Agrees to consume durian for 2 weeks 5. Agrees to maintain a low-fiber diet during the intervention 6. Have not received any antibiotics therapy, consumed prebiotics, probiotics, symbiotic /vitamin supplement, and/or TCM for at least 1 month before the start of the study 7. Have not received any medical treatment that would impact on intestinal microbiota at least 6 months before the start of the study or during the study 8. Recent COVID-19 vaccination received or infection with COVID-19 at least 2 months ago Exclusion Criteria: 1. Known or suspected sensitivity/allergy to durian 2. Multiple food/drug allergies 3. Smoker 4. History or presence of current metabolic conditions and gastrointestinal diseases 5. Diagnosed with Inflammatory Bowel Disease (IBD) or significant liver enzyme abnormality 6. Presence of current haemorrhoids or piles causing rectal bleeding when passing stool 7. Pregnant, breastfeeding or intending to conceive during study period
Where this trial is running
Singapore
- National Cancer Centre, Singapore — Singapore, Singapore (Recruiting)
Study contacts
- Principal investigator: Jason YS CHAN, MD, PhD — National Cancer Centre, Singapore
- Study coordinator: Jason YS CHAN, MD, PhD
- Email: jason.chan.y.s@singhealth.com.sg
- Phone: +65 64368000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.