Effects of e-cigarette use on health
Longitudinal Effects of E-cigarette Use on Cardiovascular and Pulmonary Health
This study is trying to see how using e-cigarettes affects heart and lung health over time in people who use them compared to those who don’t.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 600 (estimated) |
| Ages | 21 Years and up |
| Sex | All |
| Sponsor | University of Wisconsin, Madison Academic / other |
| Locations | 1 site (Madison, Wisconsin) |
| Trial ID | NCT06610838 on ClinicalTrials.gov |
What this trial studies
This research investigates the long-term health effects of electronic nicotine delivery systems (ENDS) on cardiovascular and pulmonary health. The study will recruit up to 400 long-term ENDS users and 200 control participants who do not use ENDS or combustible cigarettes. Participants will undergo comprehensive biomarker assessments over 36 months, including vital signs, blood samples, and ultrasound evaluations. The research aims to quantify how factors like usage patterns, age, and body weight influence health outcomes related to ENDS use.
Who should consider this trial
Good fit: Ideal candidates are adults aged 21 and older who have been using nicotine e-cigarettes regularly for at least 12 months.
Not a fit: Patients with serious cardiovascular or pulmonary conditions, or those who are currently pregnant, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide critical insights into the health risks associated with long-term e-cigarette use, informing public health policies and individual choices.
How similar studies have performed: While there have been studies on the effects of smoking and vaping, this specific focus on long-term ENDS use and its health impacts is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * greater than or equal to 21 years of age * has vaped a nicotine e-cigarette product at least 2 days/week for most weeks for greater than or equal to 12 months * plans to remain in catchment area for greater than or equal to 3 years * smoked 5 or fewer tobacco cigarettes in the past 6 months * no serious CV, pulmonary, or other medical problems * not currently pregnant * no plans to stop vaping Exclusion Criteria: * serious CV, pulmonary, or other medical problems (e.g., moderate or severe aortic stenosis, class III or IV heart failure, blood pressure greater than or equal to 160/100 mmHg, interstitial lung disease, sarcoidosis, Stage 3 or 4 cancer) * combusted or vaped cannabis use 3 days/week or more in the past 3 months * currently pregnant * not able to read an write English * incarceration
Where this trial is running
Madison, Wisconsin
- UW Center for Tobacco Research and Intervention — Madison, Wisconsin, United States (Recruiting)
Study contacts
- Principal investigator: Timothy Baker, PhD — University of Wisconsin, Madison
- Study coordinator: James Stein, MD
- Email: jhs@medicine.wisc.edu
- Phone: 608-262-2075
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.