Effects of e-cigarette use on health
Official title: Longitudinal Effects of E-cigarette Use on Cardiovascular and Pulmonary Health
Run by University of Wisconsin, Madison · NCT06610838 · Data updated 2026-11-12
This study is trying to see how using e-cigarettes affects heart and lung health over time in people who use them compared to those who don’t.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 21 Years and up |
| Sex | All |
| Enrollment | 600 (estimated) |
| Sponsor | University of Wisconsin, Madison Academic / other |
| Locations | 1 site (Madison, Wisconsin) |
| Status | Recruiting |
| Started | January 6, 2025 |
| Main results expected | June 30, 2029 |
| Study ends | June 30, 2029 |
| Registry record updated | December 24, 2025 |
| Trial ID | NCT06610838 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 21 and older who have been using nicotine e-cigarettes regularly for at least 12 months.
✕Probably not a fit
Patients with serious cardiovascular or pulmonary conditions, or those who are currently pregnant, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This research investigates the long-term health effects of electronic nicotine delivery systems (ENDS) on cardiovascular and pulmonary health. The study will recruit up to 400 long-term ENDS users and 200 control participants who do not use ENDS or combustible cigarettes. Participants will undergo comprehensive biomarker assessments over 36 months, including vital signs, blood samples, and ultrasound evaluations. The research aims to quantify how factors like usage patterns, age, and body weight influence health outcomes related to ENDS use.
Why it matters
Potential benefit: If successful, this study could provide critical insights into the health risks associated with long-term e-cigarette use, informing public health policies and individual choices.
How similar studies have gone: While there have been studies on the effects of smoking and vaping, this specific focus on long-term ENDS use and its health impacts is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * greater than or equal to 21 years of age * has vaped a nicotine e-cigarette product at least 2 days/week for most weeks for greater than or equal to 12 months * plans to remain in catchment area for greater than or equal to 3 years * smoked 5 or fewer tobacco cigarettes in the past 6 months * no serious CV, pulmonary, or other medical problems * not currently pregnant * no plans to stop vaping Exclusion Criteria: * serious CV, pulmonary, or other medical problems (e.g., moderate or severe aortic stenosis, class III or IV heart failure, blood pressure greater than or equal to 160/100 mmHg, interstitial lung disease, sarcoidosis, Stage 3 or 4 cancer) * combusted or vaped cannabis use 3 days/week or more in the past 3 months * currently pregnant * not able to read an write English * incarceration
Where it's running
-
UW Center for Tobacco Research and Intervention
Madison, Wisconsin, United States Recruiting
Study contacts
- Principal investigator: Timothy Baker, PhD — University of Wisconsin, Madison
- Study coordinator: James Stein, MD
- Email: jhs@medicine.wisc.edu
- Phone: 608-262-2075
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Impact of THC on E-Cigarette Use Behavior
This study is testing how different doses of THC affect daily e-cigarette users' cravings and use behavior.
-
Investigating how inflammation affects blood vessel health in e-cigarette users
This study is testing how inflammation affects blood vessel health in young adults who use e-cigarettes compared to those who don’t, while also seeing if an anti-inflammatory medication can help improve their vascular function.
-
Helping dual users of cigarettes and e-cigarettes quit smoking
This study is testing different ways to help people who smoke both cigarettes and e-cigarettes quit for good by using medications and counseling.
-
Assessing lung and heart effects of vaping in adults
This study is testing how vaping affects the lungs and heart in adults who use e-cigarettes over five years.
-
Impact of Menthol on E-Cigarette Users' Addiction and Exposure
This study is testing how menthol-flavored e-cigarettes affect addiction and exposure to harmful substances in young adults aged 21-35.
-
Testing health warning labels on e-cigarettes
This study is testing new health warning labels on e-cigarettes to see if they can change how young adults feel about using them and help them think about quitting.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.