Effects of different ventilation modes on patients after lung surgery
The Effects of Different Ventilation Modes on Patients With Plasma Inflammatory Factor and Respiratory Function in Patients With Pulmonary Lobe Resection
This study tests how different breathing support methods during lung surgery can help patients recover better and reduce inflammation afterwards.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 102 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | Zunyi Medical College Academic / other |
| Locations | 1 site (Zunyi, Guizhou) |
| Trial ID | NCT06514729 on ClinicalTrials.gov |
What this trial studies
This study investigates how various ventilation modes impact respiratory function and inflammatory factors in patients undergoing pulmonary lobe resection. Participants will be randomly assigned to one of three groups, each receiving a different combination of ventilation techniques during surgery. The aim is to determine which method optimally supports lung function and reduces inflammation post-surgery.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-75 who are scheduled for elective pulmonary lobe resection and meet specific health criteria.
Not a fit: Patients with a history of significant respiratory conditions or those requiring emergency surgery may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved respiratory outcomes and reduced complications for patients undergoing lung surgery.
How similar studies have performed: While similar studies have explored ventilation strategies, this specific approach to lung resection is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Comprehensive examination and analysis of imaging, laboratory examination and other comprehensive examinations, the diagnosis is clear, which is in line with lobe resection surgical indications Age 18-75 years old, the gender is not limited; ASA grading Ⅰ \~ III level; It is expected that the single lung ventilation time is ≥1 hours, and ≤3 hours Exclusion Criteria: Emergency surgery; There is a taboos on the existence of systemic anesthesia; There is a history of acute chronic upper respiratory infections in the past January; Previous bronchial asthma, chronic obstructive pulmonary disease, bronchial dilatation, phthisis ,aspergillosis , acute respiratory distress syndrome or history of respiratory failure; Merge the function of important organs such as heart, liver, and kidney; There was a history of chest surgery and the history of trauma; Preoperative lung function test obvious abnormal abnormal abnormalities (1 second of exhalation (FEV1) \<60%); Patients refuse to participate in the clinical trial
Where this trial is running
Zunyi, Guizhou
- Affiliated Hospital of Zunyi Medical University — Zunyi, Guizhou, China (Recruiting)
Study contacts
- Principal investigator: Zhang Hong — Chief physician of Department of Anesthesiology,Affiliated Hospital of Zunyi Medical University
- Study coordinator: Mao Enting
- Email: 2432870509@qq.com
- Phone: +0086 15736012002
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.