Effects of dietary fatty acids on brain function in older adults
Fatty Acid Modulation of Brain Function in Older Adults
NA · University of Vermont · NCT06192407
This study tests if changing the types of fats in the diet can help improve brain function in healthy older adults aged 65-75.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 65 Years to 75 Years |
| Sex | All |
| Sponsor | University of Vermont (other) |
| Locations | 1 site (Burlington, Vermont) |
| Trial ID | NCT06192407 on ClinicalTrials.gov |
What this trial studies
This study investigates how different dietary fatty acid compositions affect brain functioning in healthy older adults aged 65-75 years. Participants will follow two experimental diets with varying ratios of palmitic acid and oleic acid, preceded by a low-fat control diet. The study employs a crossover design, allowing each participant to experience both diets in a randomized order over a four-week period. The research aims to determine if reducing saturated fat intake can lead to improvements in cognitive function.
Who should consider this trial
Good fit: Ideal candidates are healthy men and women aged 65-75 years with normal cognitive function.
Not a fit: Patients with significant cognitive impairment or those on certain medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to dietary recommendations that enhance cognitive health in older adults.
How similar studies have performed: Previous studies have indicated that dietary changes can positively impact cognition, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men and women age range 65-75 years * Normal cognition (see Research Strategy for details on cognitive assessments) * "Healthy" (body mass index (BMI) of 20-40 kg/m2) Exclusion Criteria: * Significant cognitive or behavioral impairment (see Research Strategy for testing and exclusions) or pharmacological treatment for this (e.g. antipsychotics, anxiolytics, and sedative medications). * Hormone replacement therapy, past 3 months. * Hyper-androgenic condition. * HbA1C≥7.5% and or Fasting plasma glucose concentration ≥130 mg/dL. * Type 2 Diabetes if receiving any other therapy than metformin. * Use of nicotine or ingestion of caffeine or alcohol during the study. * Habitual fat intake \< 25% of kcal or strict vegetarian diet. * Sleep apnea requiring continuous positive airway pressure at night. * Lung, cardiac (heart failure or its treatment), liver disease, renal disease, cancer, and any other medical disorder known or thought to cause inflammation or abnormalities of cognition * Actively training for an athletic event or participating in competitive sports (such as league play or tournaments) * Intolerance or allergy to any of the food provided in the study.
Where this trial is running
Burlington, Vermont
- University of Vermont — Burlington, Vermont, United States (RECRUITING)
Study contacts
- Principal investigator: Julie Dumas, Ph.D. — University of Vermont
- Study coordinator: Julie Dumas, Ph.D.
- Email: julie.dumas@uvm.com
- Phone: 1(802)847-2523
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Aging, fatty acids, diet, aging, MRI, palmitic acid, oleic acid