Effects of diet on blood lipids and metabolism

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how different macronutrient compositions in diets, specifically high carbohydrate versus high fat, affect blood lipid responses and liver metabolism in adults without metabolic diseases. Participants will be randomly assigned to consume either a low carbohydrate, high-fat diet or a high carbohydrate, low-fat diet for up to 28 days while maintaining stable body weight. The study also aims to explore the interaction between dietary macronutrient content and individual genetic factors on metabolic responses. By analyzing plasma triglyceride concentrations and liver fat content, the research seeks to clarify optimal dietary approaches for reducing the risk of cardiometabolic diseases.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participant is willing and able to give informed consent for participation in the study.
* Male or Female, aged ≥18 to ≤65 years
* Body mass index (BMI) ≥19 to ≤35 kg/m2
* No medical condition or relevant drug therapy that is known to affect the liver, adipose tissue, or cardiac metabolism.
* Weight stable for the previous 3 months

Exclusion Criteria:

* Aged \<18 or \>65 years
* BMI \<19 or \>35 kg/m2
* A blood haemoglobin \<135 mg/dL for men and \<120 mg/dL for women
* Donated (or lost) ≥250 mL of blood in the previous two months
* On a weight loss diet or decreased their body weight by \>5% in the previous 3 months
* Currently adhering to or have consumed in the previous 3 months a diet with a notably altered macro-nutrient content (e.g. high-fat - low-carbohydrate diet)
* Have increased their body weight by \>5% in the previous 3 months
* Any metabolic condition or relevant drug therapy
* Current smoker
* History of alcoholism or a greater than recommended alcohol intake (\>30 g of alcohol daily for men and \>20 g of alcohol daily for women)
* History of albumin allergy.
* Pregnant or nursing mothers
* History of severe claustrophobia

Where it's running

• Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford
  Oxford, United Kingdom Recruiting
• Oxford Centre for Diabetes, Endocrinology and Metabolism
  Oxford, United Kingdom Recruiting

Study contacts

• Principal investigator: Leane Hodson — University of Oxford
• Study coordinator: David J Dearlove
• Email: david.dearlove@ocdem.ox.ac.uk
• Phone: 07739460623

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Registering medical data and care outcomes for ALS, SMA, and other motor disorders

  This registry slowly collects routine-care information from adults with ALS, SMA, or other motor disorders to see how they’re treated and how care affects outcomes.

  Recruiting Ambulanzpartner Soziotechnologie APST GmbH · Berlin, State of Berlin · NCT07900672

• Lifestyle Metabotype Study B: Understanding Personalized Glucose Responses

  This study tests how lifestyle, metabolism, and brain energy use relate to each person’s blood sugar response after meals, across people with and without prediabetes or type 2 diabetes.

  Recruiting at 2 sites German Institute of Human Nutrition · Berlin and 1 other locations · NCT07888257

• Lifestyle Metabotype Study: How Daily Habits Shape Blood Sugar

  This observational study tests whether personal lifestyle and biological factors can predict how a person’s blood sugar responds after meals.

  Recruiting German Institute of Human Nutrition · Potsdam, Potsdam-Rehbrücke · NCT07868601

• AMX0035 in adults with Type 1 Diabetes

  This study tests whether 24 weeks of the oral medication AMX0035 help improves metabolic health in adults with Type 1 Diabetes compared with a placebo.

  Recruiting Phase 2 University of Washington · Seattle, Washington and 1 other locations · NCT07699380

• Orforglipron for Type 2 Diabetes in Ramadan Fasters

  This study tests whether orforglipron helps people with type 2 diabetes who fast during Ramadan, to see if it improves blood sugar control safely.

  Recruiting at 33 sites Phase 3 Eli Lilly and Company · Agra and 39 other locations · NCT07613307

• Long-term weight loss using a galactooligosaccharide (GOS) chewing gum

  This study will see if a chewing gum containing galactooligosaccharides (GOS) helps adults with overweight (BMI >25) lower their weight and change their oral and gut microbiomes.

  Recruiting University of Bern · Bern · NCT07036692

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.