Effects of Dexmedetomidine on cognitive function after heart surgery
The Effects of Dexmedetomidine on Postoperative Cognitive Function and Neuron-Specific Enolase Levels in Open Heart Surgery
This study tests if the sedative Dexmedetomidine can help improve thinking skills and reduce brain injury in people having heart surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 32 (estimated) |
| Sex | All |
| Sponsor | Sohag University Academic / other |
| Locations | 1 site (Sohag) |
| Trial ID | NCT06655025 on ClinicalTrials.gov |
What this trial studies
This study evaluates how Dexmedetomidine, a sedative medication, influences cognitive function and serum Neuron Specific Enolase levels, which indicate neuronal injury, in patients undergoing elective open-heart surgery. The research aims to determine if this medication can mitigate cognitive decline post-surgery. Patients will be monitored for changes in cognitive abilities and neuronal damage markers following their surgical procedures.
Who should consider this trial
Good fit: Ideal candidates are patients of both sexes scheduled for elective open-heart surgery.
Not a fit: Patients with a history of neurological disorders or severe renal or liver dysfunction may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved cognitive outcomes for patients after open-heart surgery.
How similar studies have performed: Other studies have shown promising results with similar approaches, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients of both sexes undergoing elective open-heart surgery Exclusion Criteria: * Patients with a history of neurological disorders, severe renal or liver dysfunction, or contraindications to Dexmedetomidine as in patients with known QT prolongation, a history of other arrhythmias, symptomatic bradycardia, hypokalemia, or hypomagnesemia, and in patients receiving other drugs known to prolong the QT interval. Patients with cognitive impairment, mental and psychological illness and chronic alcoholics, drug addicts, abuse of psychotropic substances, illiterate education
Where this trial is running
Sohag
- Sohag University — Sohag, Egypt (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.