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Effects of Dexamethasone on Pregnant Women

Obstetrical, Endocrine and Metabolic Consequences of Antenatal Dexamethasone Treatment in Pregnant Women at Risk of Congenital Adrenal Hyperplasia

Observational Assistance Publique - Hôpitaux de Paris · NCT06259994

This study looks at how taking dexamethasone during pregnancy affects the health of mothers and their babies, including any complications like weight gain and diabetes.

Quick facts

Study typeObservational
Enrollment35 (estimated)
Ages18 Years and up
SexFemale
SponsorAssistance Publique - Hôpitaux de Paris Academic / other
Locations17 sites (Bordeaux and 16 other locations)
Trial IDNCT06259994 on ClinicalTrials.gov

What this trial studies

This observational study aims to analyze the obstetric, endocrine, and metabolic outcomes in women treated with dexamethasone (DEX) during pregnancy. It will assess the prevalence of complications such as weight gain, insomnia, edema, hypertension, and gestational diabetes, while also describing pregnancy outcomes and analyzing the corticotropic axis during and after pregnancy. The goal is to improve management strategies for these women and prevent associated comorbidities. By comparing outcomes with a reference population, the study seeks to provide a comprehensive understanding of the effects of DEX treatment in pregnancy.

Who should consider this trial

Good fit: Ideal candidates for this study are adult women (18 years and older) who are pregnant and have a medical indication for prenatal dexamethasone treatment.

Not a fit: Patients who have contraindications to dexamethasone treatment or those who object to the use of their data may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved management of pregnant women treated with dexamethasone, reducing the risk of complications.

How similar studies have performed: While previous studies have suggested complications in women treated with DEX during pregnancy, this study is novel in its comprehensive approach to evaluating pregnancy outcomes.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

1. Femme majeure (âge ≥ 18 ans)
2. Grossesse avec indication de traitement anténatal par dexaméthasone (DEX) en accord avec le PNDS :

   * Mutation sévère du gène CYP21A2 chez chacun des parents
   * Fœtus féminin
3. Grossesse unique
4. Ayant commencé un traitement anténatal par DEX depuis au moins 24h

Exclusion Criteria:

1. Contraindication to dexamethasone treatment
2. Objection to use of data
3. Persons under legal protection (curatorship, guardianship), court-appointed guardians

Where this trial is running

Bordeaux and 16 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Dexamethasone During PregnancyCongenital Adrenal Hyperplasia 21 hydroxylase pregnancy
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.