Effects of Dexamethasone and Dexmedetomidine on Nausea After Gallbladder Surgery
Comparison of Intraperitoneal Dexamethasone, Dexmedetomidine, and Dexamethasone-Dexmedetomidine Combination on Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy: A Randomized Clinical Trial
This study tests if the medications dexamethasone and dexmedetomidine, alone or together, can help prevent nausea and vomiting after gallbladder surgery.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Enrollment | 120 (estimated) |
| Ages | 20 Years to 50 Years |
| Sex | All |
| Sponsor | Al-Azhar University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 2 sites (Banhā and 1 other locations) |
| Trial ID | NCT05988671 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effectiveness of dexamethasone, dexmedetomidine, and their combination in preventing postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. It is a double-blind, phase 3 interventional study that compares these treatments against a control group receiving normal saline. The goal is to determine which approach is most effective in reducing these common postoperative complications. Participants will be monitored for nausea and vomiting following their surgery to assess the outcomes of the different interventions.
Who should consider this trial
Good fit: Ideal candidates for this study are patients aged 20 to 50 years with ASA I or II status who are scheduled for laparoscopic cholecystectomy.
Not a fit: Patients with a history of psychotic illnesses, Parkinson's disease, motion disorders, smokers, or those with a history of chemotherapy may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could significantly reduce the incidence of postoperative nausea and vomiting, improving recovery experiences for patients.
How similar studies have performed: Previous studies have shown promising results with dexamethasone and dexmedetomidine in reducing postoperative nausea and vomiting, indicating that this approach has potential based on existing evidence.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged from 20 - 50 years * ASA I OR II * undergo laparoscopic cholecystectomy Exclusion Criteria: * Patients with history of psychotic illnesses, * Parkinson's disease * motion disorder * Smoker * or history of chemotherapy
Where this trial is running
Banhā and 1 other locations
- Haney Baumey — Banhā, Egypt (Recruiting)
- Neveen Kohaf — Tanta, Egypt (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.