Effects of creatine on exercise performance at high altitude

Creatine Supplementation At Simulated Altitude

Not applicable Interventional California Polytechnic State University-San Luis Obispo · NCT06489587

This study tests if taking creatine can help military personnel perform better during exercise at high altitudes compared to a placebo.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment60 (estimated)
Ages18 Years to 40 Years
SexAll
SponsorCalifornia Polytechnic State University-San Luis Obispo Academic / other
Locations1 site (San Luis Obispo, California)
Trial IDNCT06489587 on ClinicalTrials.gov

What this trial studies

This study investigates how creatine supplementation affects exercise performance in simulated high-altitude conditions. Military personnel often face challenges in performance due to hypoxia, and while creatine is known to enhance performance at sea level, its effects at altitude are unexplored. Participants will undergo a repeated sprints test after a two-day supplementation period with either creatine or a placebo to assess differences in performance outcomes.

Who should consider this trial

Good fit: Ideal candidates are active individuals aged 18-40 with a BMI between 18.5 and 40 who engage in regular physical activity.

Not a fit: Patients who are pregnant, have recent creatine use, or have allergies to supplements may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could enhance exercise performance for individuals training or operating in high-altitude environments.

How similar studies have performed: While creatine's effects at sea level are well-documented, this specific investigation at simulated altitude is novel and has not been previously tested.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* 18-40 years old
* BMI 18.5 to 40 kg/m2
* Habitually active (\>150 minutes per week of moderate-vigorous physical activity)

Exclusion Criteria:

* Pregnant or trying to become pregnant
* Recent use of creatine supplementation
* Supplemental allergies

Where this trial is running

San Luis Obispo, California

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Exercise Performance
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.