Effects of Corpus Luteum on Frozen Embryo Transfer Pregnancies

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of the corpus luteum on pregnancies achieved through programmed frozen embryo transfer (PC-FET) and modified natural frozen embryo transfer (mNC-FET). It aims to assess differences in endothelial and placental function, maternal cardiovascular function, fetal growth, and fetal cardiovascular and cerebral programming. The study will also explore the relationship between these differences and the plasma concentrations of key secretion products from the corpus luteum that have vasoactive and angiogenic properties.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Female patients 18- 37 years old (both included) at the time of oocyte retrieval and less than 41 years of age at the time of embryo transfer.
* Regular menstrual cycles between 24 and 35 days.
* Availability of cryopreserved blastocysts from own gametes
* Indication for single embryo transfer.
* Patients who will be included in the LUTI study are candidates for either of the two procedures under study, and will have no contraindications for either procedure.

Exclusion Criteria:

* Recurrent pregnancy loss (3 or more).
* Recurrent implantation failure in previous IVF treatments (3 or more unsuccessful embryo transfers). .
* Diagnosis of polycystic ovarian syndrome, diabetes mellitus, chronic arterial hypertension, maternal heart disease and autoimmune diseases (Systemic Lupus Erythematosus (SLE) or Antiphospholipid syndrome (APS)).
* Active treatment with aspirin, heparin or other anticoagulant therapy, antihypertensives or other drugs used to treat circulation or coagulation disorders .
* Indication for PGT (Preimplantation Genetic Testing).
* Multiple pregnancy.

Where it's running

• Laura Burunat
  Barcelona, Spain, Spain Recruiting

Study contacts

• Study coordinator: Laura B Burunat, Graduate
• Email: burunat@recerca.clinic.cat
• Phone: 0034932275400

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Preventing pre-eclampsia with low-dose aspirin in women after frozen embryo transfer

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.