Effects of cerebellar TMS on cognitive functions in schizophrenia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study investigates the impact of repetitive transcranial magnetic stimulation (rTMS) on brain and cognitive functions in individuals aged 18 to 40 diagnosed with schizophrenia. A total of 60 participants will be randomly assigned to receive either active rTMS or sham rTMS alongside standard care for four weeks, with treatment sessions occurring five days a week. The study will utilize functional magnetic resonance imaging (fMRI) and cognitive assessments at baseline, mid-treatment, and post-treatment to evaluate changes in brain activity and cognitive performance.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Male or female subjects 18 to 60 years of age
2. DSM-V diagnosis of schizophrenia spectrum disorders
3. Competent to provide informed consent

Exclusion Criteria:

1. Lifetime DSM-V diagnosis of an Axis-I disorder other than schizophrenia spectrum disorders
2. Lifetime diagnosis of ataxia or other cerebellar disorders
3. Lifetime diagnosis of mental retardation, dementia, Alzheimer's disease, Parkinson's disease, Huntington's disease, or other neurodegenerative disorders
4. Any active general medical condition or CNS disease which can affect cognition or response to treatment
5. Substance dependence or abuse in the past six months
6. Seizure history
7. TMS within three months or ECT within six months
8. Pregnancy as indicated by self-report
9. MRI contraindications

Where it's running

• Zucker Hillside Hospital
  New York, New York, United States Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.