Effects of Carbon Dioxide Levels on Anesthesia in Children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of varying levels of end-tidal carbon dioxide (ETCO2) on the depth of anesthesia in children aged 3 to 11 years undergoing non-invasive or minimally stimulating elective procedures. The research aims to determine whether higher levels of CO2 can enhance sedation, reduce pain signals, and improve recovery outcomes during general anesthesia. Participants will be monitored under controlled ventilation with an endotracheal tube while their ETCO2 levels are adjusted to high normal, normal, and low normal ranges. The findings could provide insights into optimizing anesthesia practices for pediatric patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Children aged 3 - 11 years undergoing non- or minimally-stimulating elective procedures, defined as anesthesia without skin incision or painful manipulation (e.g., non-invasive imaging, auditory brainstem response testing), middle ear surgery, surgery with effective local or regional anesthesia before surgical incision (e.g dental procedures with local anesthetic infiltration, urology with regional block).
* American Society of Anesthesiologists (ASA) physical status I and II
* TIVA technique appropriate throughout induction and maintenance of anesthesia
* Controlled ventilation via endotracheal tube
* Anticipated surgical time ≥ 90 minutes: to allow time for anesthetic induction and subsequent testing and washout periods at all three EtCO2 levels.

Exclusion Criteria:

* Need for inhalational induction of anesthesia
* Sedative premedication
* Use of ketamine intraoperatively
* Unable to place BIS electrodes due to surgical site or other contraindications (e.g., MRI)
* Allergy to study drugs (propofol, remifentanil, lidocaine)
* Depression of conscious level for any reason
* BMI \<5th or \>95th centile for age
* History of obstructive or central sleep apnea
* Known or suspected raised intracranial pressure
* Recent or historical traumatic brain injury

Where it's running

• BC Children's Hospital
  Vancouver, British Columbia, Canada Recruiting

Study contacts

• Principal investigator: Christopher A Chin, MBBS, FRCA, FRCP, MA — University of British Columbia
• Study coordinator: Victoria Buswell
• Email: victoria.buswell@cw.bc.ca
• Phone: 604-875-1989

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.