Clinical trial Recruiting at 1 site Early Phase 1 Interventional Ages 18 to 50

Effects of Cannabidiol on Learning and Anxiety in College Students

Official title: Cannabidiol Effects on Learning and Anxiety

Run by University of Connecticut · NCT05283382 · Data updated 2026-11-12

This study tests if a single dose of CBD can help college students with social anxiety feel less fear after a scary exercise.

More Anxiety and Fear trials

Quick facts

PhaseEarly Phase 1
Study typeInterventional
Ages18 Years to 50 Years
SexAll
Enrollment160 (estimated)
SponsorUniversity of Connecticut
Academic / other
Locations1 site (Storrs, Connecticut)
StatusRecruiting
StartedOctober 30, 2024
Main results expectedDecember 30, 2026
Study endsFebruary 2027
Registry record updatedApril 29, 2026
Trial IDNCT05283382 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are college students aged 18-50 who exhibit elevated levels of social anxiety.

Probably not a fit

Patients with heart problems, neurological disorders, or those currently using CBD or cannabis products may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how Cannabidiol (CBD) may improve the extinction of fear responses in college students with elevated social anxiety. Participants will undergo a fear conditioning exercise where they learn to associate a face with a mild shock. Following this, half of the participants will receive a single dose of 600 mg CBD, while the other half will receive a placebo. The study will measure the effectiveness of CBD in reducing fear responses through physiological and subjective assessments.

Why it matters

Potential benefit: If successful, this study could provide a novel treatment option for individuals with social anxiety by enhancing their ability to overcome fear responses.

How similar studies have gone: While there is emerging research on CBD's effects on anxiety, this specific approach to fear conditioning extinction is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* 18-50 years of age

Exclusion Criteria:

1. Difficulties seeing a computer screen
2. Anyone currently taking CBD within the last 24 hours.
3. Anyone using any cannabis product within the last 24 hours.
4. Heart problems or heart disease
5. A neurological disorder such as epilepsy, stroke, multiple sclerosis, tumor, vascular malformations, aneurysm
6. Are currently pregnant or breast-feeding

Where it's running

  • University of Connecticut
    Storrs, Connecticut, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.