Effects of caffeine on resistance training based on genetic factors
Influence of CYP1A2 on the Prolonged Effect of Caffeine Intake on Resistance Training
NA · University of Alcala · NCT06610123
This study tests how caffeine affects strength training results based on genetic differences in men and women.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 48 (estimated) |
| Ages | 18 Years to 35 Years |
| Sex | All |
| Sponsor | University of Alcala (other) |
| Locations | 1 site (Alcalá de Henares, Madrid) |
| Trial ID | NCT06610123 on ClinicalTrials.gov |
What this trial studies
This study investigates how the CYP1A2 polymorphism affects the prolonged benefits of caffeine intake on neuromuscular adaptations during resistance training in both men and women. Participants will engage in resistance training while receiving either caffeine or a placebo to assess performance outcomes. The study aims to clarify the relationship between genetic variations and the effectiveness of caffeine as an ergogenic aid in strength training. By analyzing these interactions, the research seeks to provide insights into personalized training and supplementation strategies.
Who should consider this trial
Good fit: Ideal candidates are healthy men and women aged 18 to 35 with a BMI under 25 who are physically active.
Not a fit: Patients with a BMI of 25 or higher, or those with certain health conditions affecting exercise performance, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to personalized recommendations for caffeine use in resistance training, enhancing athletic performance based on genetic profiles.
How similar studies have performed: Previous studies have shown positive effects of caffeine on athletic performance, but this specific investigation into genetic factors is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between ≥ 18 and ≤ 35 years. * Body mass index (BMI) lowe than 25 kg/m². * Physically active subjects (≥ 150 min/week of moderate exercise). * Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from performing physical exercise. * Participants capable of performing the tests. Exclusion Criteria: * History of neuromuscular, cardiac, or diseases that could affect liver or muscle metabolism. * Use of drugs or other stimulants that interfere with caffeine intake and intestinal absorption during the tests and study. * Body mass index (BMI) ≥ 25 kg/m². * Having undergone prolonged periods of forced physical inactivity during the 6 months prior to the study. * Performing strenuous exercise within 48 hours prior to the tests. * Failing to replicate the same food intake on the two experimental days. * Consuming caffeine after 6 PM on the day prior to training or testing.
Where this trial is running
Alcalá de Henares, Madrid
- Facultad de Medicina y Ciencias de la Salud. Universidad de Alcalá — Alcalá de Henares, Madrid, Spain (RECRUITING)
Study contacts
- Study coordinator: Alberto Pérez-López, PhD
- Email: alberto.perezl@uah.es
- Phone: 918854537
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: CYP1A2 Polymorphism, Caffeine and Resistance Training