Effects of brain stimulation on cognitive impairment after stroke
The Second Hospital of Dalian Medical University
This study is testing if brain stimulation techniques can help improve thinking and memory in people who have had a stroke.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 30 Years to 80 Years |
| Sex | All |
| Sponsor | The Second Affiliated Hospital of Dalian Medical University Academic / other |
| Locations | 1 site (Dalian, Liaoning) |
| Trial ID | NCT06252987 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effectiveness of non-invasive brain stimulation techniques, specifically transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS), in improving cognitive function in stroke patients. Participants will be assigned to receive either conventional treatment, tDCS, rTMS, or a combination of tDCS and rTMS. The study aims to assess cognitive and brain function changes through various evaluations, including functional near-infrared spectroscopy. By comparing these different treatment approaches, the trial seeks to identify the most effective method for enhancing cognitive recovery post-stroke.
Who should consider this trial
Good fit: Ideal candidates are right-handed stroke patients aged 30-80 with unilateral hemiplegia and cognitive impairment.
Not a fit: Patients with cognitive impairment due to other diseases or those with severe cognitive or speech impairments may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a novel treatment option to improve cognitive function in stroke patients.
How similar studies have performed: Other studies have shown promising results using similar non-invasive brain stimulation techniques for cognitive rehabilitation, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Meet the clinical diagnostic criteria of the Expert Consensus on the Management of Cognitive Impairment after Stroke in 2021; * 30-80 years old, right-handed, unilateral hemiplegia; * Verbal expression can cooperate with the completion of the evaluation, sustained attention time is longer than 5 minutes; * Simple Mental State Examination Scale (MMSE) score ≤26 points; MoCA scale score \< 26 points; Memory test (RMBT) score less than 21 points; * patients or their family agree to sign the informed consent; * The Ethics Committee approved the trial. Exclusion Criteria: * Memory dysfunction caused by other diseases, such as Alzheimer's disease, lewy body dementia, pituitary tumor surgery, hypothyroidism, etc.; * There are contraindications of rTMS and tDCS for untreated intracranial aneurysms, severe epilepsy, intracranial metal, etc. * Patients with severe visual, cognitive or speech impairment who cannot cooperate with treatment; * The condition is not stable; Or other serious physical diseases.
Where this trial is running
Dalian, Liaoning
- Lily — Dalian, Liaoning, China (Recruiting)
Study contacts
- Study coordinator: Wuyao Pan
- Email: 331189506@qq.com
- Phone: +18186766836
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.