Effects of brain stimulation on cognitive control in epilepsy patients
A Neural Population Model-based Characterization and Modulation of Neural Oscillations Underlying Cognitive Control in Healthy and Depressed/Anxious Human Subjects.
This study tests how brain stimulation affects thinking and decision-making in people with epilepsy who are preparing for surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 5 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | University of Cincinnati Academic / other |
| Locations | 1 site (Cincinnati, Ohio) |
| Trial ID | NCT05251454 on ClinicalTrials.gov |
What this trial studies
This study investigates how brain stimulation can modulate cognitive control by recording brain signals in patients undergoing monitoring for epilepsy surgery. Participants will have electrodes implanted in brain regions associated with cognitive control, allowing researchers to study the neural mechanisms involved. The research aims to link cognitive control disruptions to specific brain circuits, providing insights that could inform future neuromodulation therapies. Participants will perform tasks designed to measure cognitive control while their brain activity is monitored.
Who should consider this trial
Good fit: Ideal candidates are adult patients undergoing EEG monitoring for pharmacologically resistant epilepsy at the University of Cincinnati Medical Center.
Not a fit: Patients with cognitive or physical impairments that limit their ability to participate in cognitive testing will not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for cognitive deficits associated with psychiatric diseases.
How similar studies have performed: While this approach is innovative, similar studies have shown promise in understanding brain function and cognitive control, though this specific methodology is less commonly tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients who are undergoing electroencephalographic (EEG) monitoring as part of a standard clinical procedure for the treatment of pharmacologically resistant epilepsy at University of Cincinnati Medical Center. Exclusion Criteria: * Patients who have cognitive or physical impairments that would limit their ability to participate in the cognitive testing will be excluded from the study. Other exclusions include adults unable to consent, non-English speaking patients, children age 17 and younger, pregnant women (note: pregnant women are not candidates for intracranial EEG monitoring), and prisoners.
Where this trial is running
Cincinnati, Ohio
- University of Cincinnati — Cincinnati, Ohio, United States (Recruiting)
Study contacts
- Study coordinator: Ishita Basu, PhD
- Email: basuia@ucmail.uc.edu
- Phone: 5135583991
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.