Effects of blood pressure medications on pregnant women
Official title: The Effect of Labetalol, Atenolol, and Nifedipine on Maternal Hemodynamics Measured by Impedance Cardiography in Early Pregnancy
Run by Marshall University · NCT04755764 · Data updated 2026-11-12
This study tests how different blood pressure medications affect pregnant women’s heart and blood flow in early pregnancy.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 60 (estimated) |
| Sponsor | Marshall University Academic / other |
| Locations | 1 site (Huntington, West Virginia) |
| Status | Recruiting |
| Started | March 3, 2021 |
| Main results expected | December 2025 |
| Study ends | December 2025 |
| Registry record updated | May 13, 2025 |
| Trial ID | NCT04755764 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are English-speaking pregnant women aged 18-45 with a gestational age of less than 15 weeks presenting with hypertension.
✕Probably not a fit
Patients who are non-English speaking, under 18 or over 45 years old, or those with a gestational age greater than 15 weeks will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This research aims to evaluate how labetalol, atenolol, and nifedipine influence maternal hemodynamics during early pregnancy. Patients visiting the Maternal Hypertension Center will undergo a non-invasive hemodynamic assessment using the NICaS system. Based on their hemodynamic measurements, patients will receive specific medications to manage their blood pressure and cardiac output. Follow-up assessments will occur one week later to monitor changes in hemodynamics.
Why it matters
Potential benefit: If successful, this study could lead to improved management of hypertension in pregnant women, enhancing maternal and fetal health outcomes.
How similar studies have gone: Other studies have shown success in managing hypertension in pregnancy with similar medications, indicating a promising approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients presenting to Maternal Hypertension Center at Cabell Huntington Hospital * English speaking * 18-45 years old. * Willing to provide informed consent * Gestational age prior to 15 weeks gestation Exclusion Criteria: * Non-English speaking patients, patients * \<18 years old or \>45 years old * Not willing or able to provide consent * Gestational age \>15 weeks
Where it's running
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Maternal Hypertension Center at Cabell Huntington Hospital
Huntington, West Virginia, United States Recruiting
Study contacts
- Principal investigator: Jesse Cottrell, MD — Marshall University
- Study coordinator: Morgan Ruley, MS
- Email: kelley115@marshall.edu
- Phone: (304) 691-1458
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.