Clinical trial Recruiting at 1 site Observational Ages 18 to 45 Women only

Effects of blood pressure medications on pregnant women

Official title: The Effect of Labetalol, Atenolol, and Nifedipine on Maternal Hemodynamics Measured by Impedance Cardiography in Early Pregnancy

Run by Marshall University · NCT04755764 · Data updated 2026-11-12

This study tests how different blood pressure medications affect pregnant women’s heart and blood flow in early pregnancy.

More Pregnancy Related trials

Quick facts

Study typeObservational
Ages18 Years to 45 Years
SexWomen only
Enrollment60 (estimated)
SponsorMarshall University
Academic / other
Locations1 site (Huntington, West Virginia)
StatusRecruiting
StartedMarch 3, 2021
Main results expectedDecember 2025
Study endsDecember 2025
Registry record updatedMay 13, 2025
Trial IDNCT04755764 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are English-speaking pregnant women aged 18-45 with a gestational age of less than 15 weeks presenting with hypertension.

Probably not a fit

Patients who are non-English speaking, under 18 or over 45 years old, or those with a gestational age greater than 15 weeks will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research aims to evaluate how labetalol, atenolol, and nifedipine influence maternal hemodynamics during early pregnancy. Patients visiting the Maternal Hypertension Center will undergo a non-invasive hemodynamic assessment using the NICaS system. Based on their hemodynamic measurements, patients will receive specific medications to manage their blood pressure and cardiac output. Follow-up assessments will occur one week later to monitor changes in hemodynamics.

Why it matters

Potential benefit: If successful, this study could lead to improved management of hypertension in pregnant women, enhancing maternal and fetal health outcomes.

How similar studies have gone: Other studies have shown success in managing hypertension in pregnancy with similar medications, indicating a promising approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients presenting to Maternal Hypertension Center at Cabell Huntington Hospital
* English speaking
* 18-45 years old.
* Willing to provide informed consent
* Gestational age prior to 15 weeks gestation

Exclusion Criteria:

* Non-English speaking patients, patients
* \<18 years old or \>45 years old
* Not willing or able to provide consent
* Gestational age \>15 weeks

Where it's running

  • Maternal Hypertension Center at Cabell Huntington Hospital
    Huntington, West Virginia, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.