Effects of blood pressure medications on pregnant women
The Effect of Labetalol, Atenolol, and Nifedipine on Maternal Hemodynamics Measured by Impedance Cardiography in Early Pregnancy
This study tests how different blood pressure medications affect pregnant women’s heart and blood flow in early pregnancy.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | Female |
| Sponsor | Marshall University Academic / other |
| Locations | 1 site (Huntington, West Virginia) |
| Trial ID | NCT04755764 on ClinicalTrials.gov |
What this trial studies
This research aims to evaluate how labetalol, atenolol, and nifedipine influence maternal hemodynamics during early pregnancy. Patients visiting the Maternal Hypertension Center will undergo a non-invasive hemodynamic assessment using the NICaS system. Based on their hemodynamic measurements, patients will receive specific medications to manage their blood pressure and cardiac output. Follow-up assessments will occur one week later to monitor changes in hemodynamics.
Who should consider this trial
Good fit: Ideal candidates are English-speaking pregnant women aged 18-45 with a gestational age of less than 15 weeks presenting with hypertension.
Not a fit: Patients who are non-English speaking, under 18 or over 45 years old, or those with a gestational age greater than 15 weeks will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management of hypertension in pregnant women, enhancing maternal and fetal health outcomes.
How similar studies have performed: Other studies have shown success in managing hypertension in pregnancy with similar medications, indicating a promising approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients presenting to Maternal Hypertension Center at Cabell Huntington Hospital * English speaking * 18-45 years old. * Willing to provide informed consent * Gestational age prior to 15 weeks gestation Exclusion Criteria: * Non-English speaking patients, patients * \<18 years old or \>45 years old * Not willing or able to provide consent * Gestational age \>15 weeks
Where this trial is running
Huntington, West Virginia
- Maternal Hypertension Center at Cabell Huntington Hospital — Huntington, West Virginia, United States (Recruiting)
Study contacts
- Principal investigator: Jesse Cottrell, MD — Marshall University
- Study coordinator: Morgan Ruley, MS
- Email: kelley115@marshall.edu
- Phone: (304) 691-1458
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.