Effects of Atogepant on Neurophysiology and Biomolecules in Migraine

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the neurophysiological and biochemical changes resulting from a 3-month treatment with atogepant in patients experiencing high-frequency episodic migraines. Participants will undergo various assessments, including High-Density EEG and biomolecular profiling, to understand the drug's impact on brain connectivity and migraine pathways. The findings will help identify predictors of treatment response and explore alternative therapeutic targets for those who do not respond to atogepant.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Individuals aged between 18 and 70;
* Diagnosis of episodic migraine according to ICHD-3 criteria;
* Monthly migraine days between 8 and 14 (high-frequency episodic migraine pattern) in the 3 months before screening;
* Individuals naïve to CGRP-targeted treatments;
* No more than one ongoing migraine preventive treatment with a stable dose for at least 3 months.

Exclusion Criteria:

* Contraindications to atogepant;
* History of serious psychiatric conditions;
* Diagnosis of other primary or secondary headaches (only sporadic tension-type headache is allowed);
* Medical conditions considered clinically significant by the investigator;
* Chronic pain conditions that need chronic treatment;
* Abuse of alcohol and/or drugs;
* Pregnancy or breastfeeding.

Where it's running

• Headache Science & Neurorehabilitation Center
  Pavia, Pavia, Italy Recruiting

Study contacts

• Study coordinator: Francescantonio Cammarota, MD
• Email: francesco.cammarota@mondino.it
• Phone: 00390382380425

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.