Effects of an antioxidant supplement on blood vessel health in healthy adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of an antioxidant supplement on vascular function in healthy non-Hispanic Black adults, who are at higher risk for cardiovascular disease. It aims to determine if oxidative stress from mitochondria contributes to vascular dysfunction, potentially leading to hypertension and cardiovascular issues. Participants will receive either the antioxidant supplement MitoQ, MitoTempo, Tempol, or a placebo to assess changes in blood vessel health. The study focuses on understanding the role of oxidative stress in maintaining cardiovascular health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Self-identify as either non-Hispanic Black or non-Hispanic White.
* Men and women 18-75 years old.
* Non-hypertensive (systolic blood pressure \[SBP\]\<130 and diastolic blood pressure \[DBP\] \<85 mmHg).
* Have low density lipoprotein cholesterol \<150mg/dl.
* Have HbA1C \<6.0%.

Exclusion Criteria:

* Rash, skin disease, or disorders of pigmentation (e.g., psoriasis, eczema, vitiligo, or other skin inflammatory skin disorders)
* Known skin allergies to latex or adhesives
* Smoking and/or use of nicotine-containing products within the past year
* Use of illegal/recreational drugs
* Generalized kidney disease
* Taking chloramphenicol, cholestyramine, medication for seizures, methotrexate, nitrofurantoin, tetracycline, barbiturates, steroids, phenobarbital/phenytoin, orlistat or pyrimethamine
* Any current medications which could conceivably alter the cardiovascular control or responses
* Diagnosed or suspected metabolic or cardiovascular disease
* Current pregnancy or breastfeeding
* History of skin or other cancers
* Diagnosed or suspected diabetes (HbA1c ≥6.0)
* Anybody with narcolepsy or who has been diagnosed with any condition that impairs body temperature regulation.

Where it's running

• Ramsey Student Center, University of Georgia
  Athens, Georgia, United States Recruiting

Study contacts

• Study coordinator: S. Tony Wolf
• Email: stwolf@uga.edu
• Phone: 706-542-4378

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.