Effects of adrenal incidentalomas on heart and metabolism

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the cardiovascular and metabolic changes in patients with adrenal incidentalomas and possible autonomous cortisol secretion (pACS). It aims to determine the impact of surgical intervention, specifically adrenalectomy, versus conservative management on these health parameters over a five-year follow-up period. The study will assess patients with non-functioning adrenal adenomas, those receiving conservative treatment, and those undergoing surgery, comparing their outcomes to patients without adrenal masses. Data will be collected at baseline, one year, and five years post-intervention to evaluate the effectiveness of the treatment approaches.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Incidentally detected adrenal mass

Exclusion Criteria:

* Patients with overt Cushing's syndrome, pheochromocytoma, Conn syndrome, adrenocortical carcinoma, late-onset congenital adrenal hyperplasia, adrenal metastasis and adrenal hemorrhage
* Patients taking medications influencing glucocorticoid production or metabolism
* Patients with psychiatric diseases or alcohol abuse
* Pregnancy

Where it's running

• Department of Experimental Medicine
  Rome, Italy, Italy Recruiting

Study contacts

• Principal investigator: Andrea M Isidori, MD, PHD — Sapienza

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.