Effects of Active and Passive Exercise on Vascular Function
Active and Passive Exercise Training in Improving Vascular Function: Local vs Systemic Vascular Effect
This study tests whether doing active leg exercises is better for improving blood vessel function than just stretching, to help understand how exercise can boost heart health.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 36 (estimated) |
| Ages | 20 Years to 30 Years |
| Sex | All |
| Sponsor | University of Milan Academic / other |
| Locations | 1 site (Milan) |
| Trial ID | NCT04758754 on ClinicalTrials.gov |
What this trial studies
This study investigates how different types of exercise, specifically active and passive training, affect vascular function both locally and systemically. It focuses on the impact of a single leg knee extension exercise compared to passive static stretching. The goal is to determine whether active training leads to greater improvements in vascular function in the arteries supplying the muscles involved in the exercise, as well as in other areas of the body. By clarifying these effects, the study aims to enhance understanding of exercise's role in cardiovascular health.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals without neurological, vascular, or musculoskeletal disorders who are not on medications affecting vascular response.
Not a fit: Patients with existing neurological, vascular, or musculoskeletal disorders, or those on specific pharmacological therapies, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into optimal exercise regimens for improving vascular health and cardiovascular well-being.
How similar studies have performed: While there have been studies on the effects of exercise on vascular function, this specific comparison of active versus passive training is less commonly explored, making it a novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: \- Exclusion Criteria: * neurological, vascular and musculoskeletal disorders of the lower and upper limbs; * being on pharmacological therapy related to either neural and/or vascular response, including hormonal contraceptives and oral supplements; * being a current or former smoker; * having an irregular menstrual cycle (26 to 35 days) up to 3 months before the beginning of the study; * contraindications to joint mobilization; regular involvement in a SLKE or PS training programme.
Where this trial is running
Milan
- Department of Biomedical Science for Health — Milan, Italy (Recruiting)
Study contacts
- Study coordinator: Emiliano Cè, PhD
- Email: emiliano.ce@unimi.it
- Phone: 0039 02 50314643
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.