Clinical trial No longer in our active list Interventional Ages 40 to 80

Effects of Action Observation and Motor Imagery on Muscle Inhibition in Knee Osteoarthritis

Official title: Effect of Action Observation and Motor Imagery on Arthrogenic Muscle Inhibition of the Quadriceps in Patients With End-stage Knee Gonarthrosis.

Run by Istituto Clinico Humanitas · NCT06000345 · Data updated 2026-05-14

This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.

This study tests if watching movements and imagining doing exercises can help improve muscle function in people with severe knee osteoarthritis.

More Knee Osteoarthritis trials

Quick facts

Study typeInterventional
Ages40 Years to 80 Years
SexAll
Enrollment30 (estimated)
SponsorIstituto Clinico Humanitas
Academic / other
Locations1 site (Rozzano)
Trial IDNCT06000345 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are patients with end-stage knee osteoarthritis who are preparing for total knee arthroplasty and have active knee flexion greater than 45 degrees.

Probably not a fit

Patients who have had previous lower limb orthopedic surgery or have neurological, orthopedic, cardiovascular disorders, or cognitive impairments may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the impact of a single session of Action Observation Training (AOT) and Motor Imagery (MI) on arthrogenic muscle inhibition (AMI) of the quadriceps in patients with end-stage knee osteoarthritis. Thirty patients are randomized into an experimental group, which undergoes AOT and MI focused on quadriceps contractions, and a control group that receives a sham intervention. The effectiveness of the interventions is assessed using the Twitch Interpolated Technique to measure AMI before and after the treatment. The study aims to determine if these techniques can improve muscle function in affected patients.

Why it matters

Potential benefit: If successful, this approach could enhance muscle function and rehabilitation outcomes for patients with knee osteoarthritis.

How similar studies have gone: While the specific combination of AOT and MI for this condition is novel, similar approaches have shown promise in enhancing rehabilitation outcomes in other musculoskeletal disorders.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* patients with end-stage knee ostheoarthritis undergoing primary total knee arthroplasty
* Active knee flexion \> 45°

Exclusion Criteria:

* Previous lower limb orthopedic surgery
* Concomitant neurological, orthopedic, cardiovascular disorders
* Cognitive impairments or psychiatric disorders

Where it's running

  • Istituto Clinico Humanitas
    Rozzano, Italy
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.